Grayson Sipe
Assistant Professor of Biology
-
224 Huck Life Sciences
University Park, PA - gos5257@psu.edu
Research Summary
Studying the molecular and cellular mechanisms that drive shifts in arousal, which are crucial for understanding maladaptive arousal in neuropsychiatric disorders such as anxiety and addiction.
Huck Graduate Students
Huck Affiliations
- Neuroscience
- Molecular, Cellular, and Integrative Biosciences
- Center for Cellular Dynamics
- Center for Molecular Investigation of Neurological Disorders
- Neuroscience Institute
- Center for Neurotechnology in Mental Health Research
- Center for Brain, Behavior, and Cognition
Links
Most Recent Publications
A paradigm for ethanol consumption in head-fixed mice during prefrontal cortical two-photon calcium imaging
Anagha Kalelkar, Grayson Sipe, Ana Raquel Castro E Costa, Ilka M. Lorenzo, My Nguyen, Ivan Linares-Garcia, Elena Vazey, Rafiq Huda, 2024, Neuropharmacology
Astrocyte glutamate uptake coordinates experience-dependent, eye-specific refinement in developing visual cortex
Grayson O. Sipe, Jeremy Petravicz, Rajeev V. Rikhye, Rodrigo Garcia, Nikolaos Mellios, Mriganka Sur, 2021, GLIA on p. 1723-1735
Distinct prefrontal top-down circuits differentially modulate sensorimotor behavior
Rafiq Huda, Grayson O. Sipe, Vincent Breton-Provencher, K. Guadalupe Cruz, Gerald N. Pho, Elie Adam, Liadan M. Gunter, Austin Sullins, Ian R. Wickersham, Mriganka Sur, 2020, Nature Communications
Author Correction: Noradrenergic signaling in the wakeful state inhibits microglial surveillance and synaptic plasticity in the mouse visual cortex (Nature Neuroscience, (2019), 22, 11, (1782-1792), 10.1038/s41593-019-0514-0)
Rianne D. Stowell, Grayson O. Sipe, Ryan P. Dawes, Hanna N. Batchelor, Katheryn A. Lordy, Brendan S. Whitelaw, Mark B. Stoessel, Jean M. Bidlack, Edward Brown, Mriganka Sur, Ania K. Majewska, 2020, Nature Neuroscience on p. 152
Noradrenergic signaling in the wakeful state inhibits microglial surveillance and synaptic plasticity in the mouse visual cortex
Rianne D. Stowell, Grayson O. Sipe, Ryan P. Dawes, Hanna N. Batchelor, Katheryn A. Lordy, Brendan S. Whitelaw, Mark B. Stoessel, Jean M. Bidlack, Edward Brown, Mriganka Sur, Ania K. Majewska, 2019, Nature Neuroscience on p. 1782-1792
Microglial P2Y12 is necessary for synaptic plasticity in mouse visual cortex
G. O. Sipe, R. L. Lowery, M. Tremblay, E. A. Kelly, C. E. Lamantia, A. K. Majewska, 2016, Nature Communications
Effects of Developmental Alcohol Exposure on Potentiation and Depression of Visual Cortex Responses
Crystal L. Lantz, Grayson O. Sipe, Elissa L. Wong, Ania K. Majewska, Alexandre E. Medina, 2015, Alcoholism: Clinical and Experimental Research on p. 1434-1442
Fluoxetine modulates breast cancer metastasis to the brain in a murine model
Yuriy Shapovalov, Martha Zettel, Sara C. Spielman, Stacy A. Amico-Ruvio, Emily A. Kelly, Grayson O. Sipe, Ian M. Dickerson, Ania K. Majewska, Edward B. Brown, 2014, BMC Cancer
Spectral sensitivity of the photointrinsic iris in the red-eared slider turtle (Trachemys scripta elegans)
Grayson O. Sipe, James R. Dearworth, Brian P. Selvarajah, Justin F. Blaum, Tory E. Littlefield, Deborah A. Fink, Corinne N. Casey, David H. McDougal, 2011, Vision Research on p. 120-130
Consensual pupillary light response in the red-eared slider turtle (Trachemys scripta elegans)
James R. Dearworth, Grayson O. Sipe, Lori J. Cooper, Erin E. Brune, Angela L. Boyd, Rhae A.L. Riegel, 2010, Vision Research on p. 598-605
Most-Cited Papers
Microglial P2Y12 is necessary for synaptic plasticity in mouse visual cortex
G. O. Sipe, R. L. Lowery, M. Tremblay, E. A. Kelly, C. E. Lamantia, A. K. Majewska, 2016, Nature Communications
Noradrenergic signaling in the wakeful state inhibits microglial surveillance and synaptic plasticity in the mouse visual cortex
Rianne D. Stowell, Grayson O. Sipe, Ryan P. Dawes, Hanna N. Batchelor, Katheryn A. Lordy, Brendan S. Whitelaw, Mark B. Stoessel, Jean M. Bidlack, Edward Brown, Mriganka Sur, Ania K. Majewska, 2019, Nature Neuroscience on p. 1782-1792
Distinct prefrontal top-down circuits differentially modulate sensorimotor behavior
Rafiq Huda, Grayson O. Sipe, Vincent Breton-Provencher, K. Guadalupe Cruz, Gerald N. Pho, Elie Adam, Liadan M. Gunter, Austin Sullins, Ian R. Wickersham, Mriganka Sur, 2020, Nature Communications
Fluoxetine modulates breast cancer metastasis to the brain in a murine model
Yuriy Shapovalov, Martha Zettel, Sara C. Spielman, Stacy A. Amico-Ruvio, Emily A. Kelly, Grayson O. Sipe, Ian M. Dickerson, Ania K. Majewska, Edward B. Brown, 2014, BMC Cancer
Effects of Developmental Alcohol Exposure on Potentiation and Depression of Visual Cortex Responses
Crystal L. Lantz, Grayson O. Sipe, Elissa L. Wong, Ania K. Majewska, Alexandre E. Medina, 2015, Alcoholism: Clinical and Experimental Research on p. 1434-1442
Astrocyte glutamate uptake coordinates experience-dependent, eye-specific refinement in developing visual cortex
Grayson O. Sipe, Jeremy Petravicz, Rajeev V. Rikhye, Rodrigo Garcia, Nikolaos Mellios, Mriganka Sur, 2021, GLIA on p. 1723-1735
Author Correction: Noradrenergic signaling in the wakeful state inhibits microglial surveillance and synaptic plasticity in the mouse visual cortex (Nature Neuroscience, (2019), 22, 11, (1782-1792), 10.1038/s41593-019-0514-0)
Rianne D. Stowell, Grayson O. Sipe, Ryan P. Dawes, Hanna N. Batchelor, Katheryn A. Lordy, Brendan S. Whitelaw, Mark B. Stoessel, Jean M. Bidlack, Edward Brown, Mriganka Sur, Ania K. Majewska, 2020, Nature Neuroscience on p. 152
A paradigm for ethanol consumption in head-fixed mice during prefrontal cortical two-photon calcium imaging
Anagha Kalelkar, Grayson Sipe, Ana Raquel Castro E Costa, Ilka M. Lorenzo, My Nguyen, Ivan Linares-Garcia, Elena Vazey, Rafiq Huda, 2024, Neuropharmacology