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University Park, PA 16802
Research in my lab focuses on the role of Transforming Growth Factor-beta in cutaneous inflammation and cancer development, and how the immune system responds to epithelial cells with activated oncogenes such as Ras. We are also interested in signaling pathways that regulate senescence of premalignant epithelial cells and how cells escape from oncogene-induced senescence.
ER stress and distinct outputs of the IRE1α RNase control proliferation and senescence in response to oncogenic Ras. Blazanin N, Son J, Craig-Lucas AB, John CL, Breech KJ, Podolsky MA, Glick AB. Proc Natl Acad Sci U S A. 114: 9900-9905, 2017.
Differentiated State of Initiating Tumor Cells Is Key to Distinctive Immune Responses Seen in H-RasG12V-Induced Squamous Tumors. Podolsky MA, Bailey JT, Gunderson AJ, Oakes CJ, Breech K, Glick AB. Cancer Immunol Res. 5:198-210, 2017.