Xin Zhang

Assistant Professor of Chemistry; Assistant Professor of Biochemistry and Molecular Biology; Paul Berg Early Career Professorship in the Eberly College of Science

Xin Zhang

Research Summary

Developing chemical tools to monitor cellular stresses that influence protein folding in real time. Deciphering how the energy landscapes associated with proper protein folding and function are regulated by the cellular folding environment. Examining how this regulation leads to significant biological consequences.

Huck Affiliations


Publication Tags

Proteins Agglomeration Fluorescence Signal Recognition Particle Fluorophores Viscosity Imaging Techniques Signal Peptide Receptor Protein Aggregates Molecules Sensors Rotors Nanoparticles Dna Oligomers Visualization Proteostasis Electrons Membranes Protein Transport Benzene Cerium Oxide Photolithography Oxidation Reduction Cations

Most Recent Papers

A General Strategy to Control Viscosity Sensitivity of Molecular Rotor-Based Fluorophores

Songtao Ye, Han Zhang, Jinyu Fei, Charles H. Wolstenholme, Xin Zhang, 2021, Angewandte Chemie - International Edition on p. 1339-1346

When aggregation-induced emission meets protein aggregates

S. Tang, S. Ye, Xin Zhang, 2021, Nat. Sci. Rev.


Charles H. Wolstenholme, Hang Hu, Songtao Ye, Brian E. Funk, Divya Jain, Chia Heng Hsiung, Gang Ning, Yu Liu, Xiaosong Li, Xin Zhang, 2020, Journal of the American Chemical Society on p. 17515-17523

Visualizing and Manipulating Biological Processes by Using HaloTag and SNAP-Tag Technologies

Conner A. Hoelzel, Xin Zhang, 2020, ChemBioChem on p. 1935-1946

A General Strategy to Enhance Donor-Acceptor Molecules Using Solvent-Excluding Substituents

Conner A. Hoelzel, Hang Hu, Charles H. Wolstenholme, Basel A. Karim, Kyle T. Munson, Kwan Ho Jung, Han Zhang, Yu Liu, Hemant P. Yennawar, John B. Asbury, Xiaosong Li, Xin Zhang, 2020, Angewandte Chemie - International Edition on p. 4785-4792

Fluorogenic detection of protein aggregates in live cells using the AggTag method

Kwan Ho Jung, Xin Zhang, 2020, on p. 1-22

Visualizing and Modulating Biological Processes Using Self-Labeling Protein Tags

Conner Hoelzel, Xin Zhang, 2020, CHEMBIOCHEM on p. 1935-1946

Super-resolution optical lithography with DNA

Shi Ho Kim, Yu Liu, Conner Hoelzel, Xin Zhang, Tae Hee Lee, 2019, Nano Letters on p. 6035-6042

A Fluorogenic AggTag Method Based on Halo- and SNAP-Tags to Simultaneously Detect Aggregation of Two Proteins in Live Cells

Kwan Ho Jung, Sojung F. Kim, Yu Liu, Xin Zhang, 2019, ChemBioChem on p. 1078-1087

Quantification of Cellular Proteostasis in Live Cells by Fluorogenic Assay Using the AgHalo Sensor

Matthew Fares, Xin Zhang, 2019, Current protocols in chemical biology on p. e58

Most-Cited Papers

Signal recognition particle

David Akopian, Kuang Shen, Xin Zhang, Shu Ou Shan, 2013, Annual Review of Biochemistry on p. 693-721

Apoferritin-CeO <sub>2</sub> nano-truffle that has excellent artificial redox enzyme activity

Xiangyou Liu, Wei Wei, Quan Yuan, Xin Zhang, Ning Li, Yuguang Du, Guanghui Ma, Chunhua Yan, Ding Ma, 2012, Chemical Communications on p. 3155-3157

Mechanisms of transthyretin inhibition of β-amyloid aggregation in vitro

Xinyi Li, Xin Zhang, Ali Reza A. Ladiwala, Deguo Du, Jay K. Yadav, Peter M. Tessier, Peter E. Wright, Jeffery W. Kelly, Joel N. Buxbaum, 2013, Journal of Neuroscience on p. 19423-19433

Modulation of fluorescent protein chromophores to detect protein aggregation with turn-on fluorescence

Yu Liu, Charles H. Wolstenholme, Gregory C. Carter, Hongbin Liu, Hang Hu, Leeann S. Grainger, Kun Miao, Matthew Fares, Conner A. Hoelzel, Hemant P. Yennawar, Gang Ning, Manyu Du, Lu Bai, Xiaosong Li, Xin Zhang, 2018, Journal of the American Chemical Society on p. 7381-7384

Molecular dynamics simulation reveals preorganization of the chloroplast FtsY towards complex formation induced by GTP binding

Ming Jun Yang, Xue Qin Pang, Xin Zhang, Ke Li Han, 2011, Journal of Structural Biology on p. 57-66

Fidelity of cotranslational protein targeting by the signal recognition particle

Xin Zhang, Shu Ou Shan, 2014, Annual Review of Biophysics on p. 381-408

Carbon nitride nanothread crystals derived from pyridine

Xiang Li, Tao Wang, Pu Duan, Maria Baldini, Haw Tyng Huang, Bo Chen, Stephen J. Juhl, Daniel Koeplinger, Vincent Henry Crespi, Klaus Schmidt-Rohr, Roald Hoffmann, Nasim Alem, Malcolm Guthrie, Xin Zhang, John V. Badding, 2018, Journal of the American Chemical Society on p. 4969-4972

The cation-Pi interaction enables a halo-tag fluorogenic probe for fast no-wash live cell imaging and gel-free protein quantification

Yu Liu, Kun Miao, Noah P. Dunham, Hongbin Liu, Matthew Fares, Amie K. Boal, Xiaosong Li, Xin Zhang, 2017, Biochemistry on p. 1585-1595

AgHalo: A facile fluorogenic sensor to detect drug induced proteome stress

Yu Liu, Matthew Fares, Noah P. Dunham, Zi Gao, Kun Miao, Xueyuan Jiang, Samuel S. Bollinger, Amie Kathleen Boal, Xin Zhang, 2017, Angewandte Chemie - International Edition on p. 8672-8676

Individual and collective contributions of chaperoning and degradation to protein homeostasis in E. coli

Younhee Cho, Xin Zhang, Kristine Faye R. Pobre, Yu Liu, David L. Powers, Jeffery W. Kelly, Lila M. Gierasch, Evan T. Powers, 2015, Cell Reports on p. 321-333