Xin Zhang

Assistant Professor of Chemistry; Assistant Professor of Biochemistry and Molecular Biology; Paul Berg Early Career Professorship in the Eberly College of Science

Xin Zhang

Research Summary

Developing chemical tools to monitor cellular stresses that influence protein folding in real time. Deciphering how the energy landscapes associated with proper protein folding and function are regulated by the cellular folding environment. Examining how this regulation leads to significant biological consequences.

Huck Affiliations

Links

Publication Tags

Proteins Fluorescence Signal Recognition Particle Sensors Proteome Enzymes Imaging Techniques Gels Cations Protein Transport Molecules Ligands Nanoparticles Gtp Phosphohydrolases Benzo 1,2,3 Thiadiazole Fluorophores Agglomeration Enzyme Activity Dna Electrons Prealbumin Signal Peptide Receptor Oxidation Reduction Molecular Dynamics Simulation Photolithography

Most Recent Papers

Super-Resolution Optical Lithography with DNA

Shi Ho Kim, Yu Liu, Conner Hoelzel, Xin Zhang, Tae Hee Lee, 2019, Nano letters on p. 6035-6042

A Fluorogenic AggTag Method Based on Halo- and SNAP-Tags to Simultaneously Detect Aggregation of Two Proteins in Live Cells

Kwan Ho Jung, Sojung F. Kim, Yu Liu, Xin Zhang, 2019, ChemBioChem on p. 1078-1087

A HaloTag-Based Multicolor Fluorogenic Sensor Visualizes and Quantifies Proteome Stress in Live Cells Using Solvatochromic and Molecular Rotor-Based Fluorophores

Yu Liu, Kun Miao, Yinghao Li, Matthew Fares, Shuyuan Chen, Xin Zhang, 2018, Biochemistry on p. 4663-4674

NMR Measurements Reveal the Structural Basis of Transthyretin Destabilization by Pathogenic Mutations

Benjamin I. Leach, Xin Zhang, Jeffery W. Kelly, H. Jane Dyson, Peter E. Wright, 2018, Biochemistry on p. 4421-4430

Role of HSP90 in the Regulation of de Novo Purine Biosynthesis

Anthony M. Pedley, Georgios I. Karras, Xin Zhang, Susan Lindquist, Stephen Benkovic, 2018, Biochemistry on p. 3217-3221

A Molecular Rotor-Based Halo-Tag Ligand Enables a Fluorogenic Proteome Stress Sensor to Detect Protein Misfolding in Mildly Stressed Proteome

Matthew Fares, Yinghao Li, Yu Liu, Kun Miao, Zi Gao, Yufeng Zhai, Xin Zhang, 2018, Bioconjugate Chemistry on p. 215-224

The Cation−π Interaction Enables a Halo-Tag Fluorogenic Probe for Fast No-Wash Live Cell Imaging and Gel-Free Protein Quantification

Yu Liu, Kun Miao, Noah P. Dunham, Hongbin Liu, Matthew Fares, Amie K. Boal, Xiaosong Li, Xin Zhang, 2017, Biochemistry on p. 1585-1595

AgHalo

Yu Liu, Matthew Fares, Noah P. Dunham, Zi Gao, Kun Miao, Xueyuan Jiang, Samuel S. Bollinger, Amie Kathleen Boal, Xin Zhang, 2017, Angewandte Chemie - International Edition on p. 8672-8676

Fluorescence Turn-On Folding Sensor to Monitor Proteome Stress in Live Cells

Yu Liu, Xin Zhang, Wentao Chen, Yun Lei Tan, Jeffery W. Kelly, 2015, Journal of the American Chemical Society on p. 11303-11311

De Novo-designed enzymes as small-molecule-regulated fluorescence imaging tags and fluorescent reporters

Yu Liu, Xin Zhang, Yun Lei Tan, Gira Bhabha, Damian C. Ekiert, Yakov Kipnis, Sinisa Bjelic, David Baker, Jeffery W. Kelly, 2014, Journal of the American Chemical Society on p. 13102-13105

Most-Cited Papers

Sequential checkpoints govern substrate selection during cotranslational protein targeting

Xin Zhang, Rumana Rashid, Kai Wang, Shu Ou Shan, 2010, Science on p. 757-760

Apoferritin-CeO <sub>2</sub> nano-truffle that has excellent artificial redox enzyme activity

Xiangyou Liu, Wei Wei, Quan Yuan, Xin Zhang, Ning Li, Yuguang Du, Guanghui Ma, Chunhua Yan, Ding Ma, 2012, Chemical Communications on p. 3155-3157

Mechanisms of transthyretin inhibition of β-amyloid aggregation in vitro

Xinyi Li, Xin Zhang, Ali Reza A. Ladiwala, Deguo Du, Jay K. Yadav, Peter M. Tessier, Peter E. Wright, Jeffery W. Kelly, Joel N. Buxbaum, 2013, Journal of Neuroscience on p. 19423-19433

Molecular dynamics simulation reveals preorganization of the chloroplast FtsY towards complex formation induced by GTP binding

Ming Jun Yang, Xue Qin Pang, Xin Zhang, Ke Li Han, 2011, Journal of Structural Biology on p. 57-66

Molecular dynamics simulation of SRP GTPases

Mingjun Yang, Xin Zhang, Keli Han, 2010, Proteins: Structure, Function and Bioinformatics on p. 2222-2237

Fidelity of cotranslational protein targeting by the signal recognition particle

Xin Zhang, Shu Ou Shan, 2014, Annual Review of Biophysics on p. 381-408

Synergistic actions between the SRP RNA and translating ribosome allow efficient delivery of the correct cargos during cotranslational protein targeting KUANG

Kuang Shen, Xin Zhang, Shu Ou Shan, 2011, RNA on p. 892-902

Direct visualization reveals dynamics of a transient intermediate during protein assembly

Xin Zhang, Vinh Q. Lam, Yun Mou, Tetsunari Kimura, Jaeyoon Chung, Sowmya Chandrasekar, Jay R. Winkler, Stephen L. Mayo, Shu Ou Shan, 2011, Proceedings of the National Academy of Sciences of the United States of America on p. 6450-6455

Small molecule probes to quantify the functional fraction of a specific protein in a cell with minimal folding equilibrium shifts

Yu Liu, Yun Lei Tan, Xin Zhang, Gira Bhabha, Damian C. Ekiert, Joseph C. Genereux, Younhee Cho, Yakov Kipnis, Sinisa Bjelic, David Baker, Jeffery W. Kelly, 2014, Proceedings of the National Academy of Sciences of the United States of America on p. 4449-4454

The Cation−π Interaction Enables a Halo-Tag Fluorogenic Probe for Fast No-Wash Live Cell Imaging and Gel-Free Protein Quantification

Yu Liu, Kun Miao, Noah P. Dunham, Hongbin Liu, Matthew Fares, Amie K. Boal, Xiaosong Li, Xin Zhang, 2017, Biochemistry on p. 1585-1595