Xiaojun Lian

Assistant Professor of Biomedical Engineering

Xiaojun Lian

Research Summary

Human Stem Cell Engineering; Genome Editing via CRISPR-Cas9; Epigenome Editing and Epigenetics.

Huck Affiliations

Links

Publication Tags

Stem Cells Pluripotent Stem Cells Cells Cardiac Myocytes Endothelin 1 Mechanics Proteins Human Embryonic Stem Cells Endothelial Cells Transforming Growth Factor Beta Catenins Beta Catenin Neoplasms Blood Vessels Genes Therapeutics Intercellular Signaling Peptides And Proteins Muscle Cell Line Modulation Expansion Endothelial Progenitor Cells Breast Neoplasms Curing Derivation

Most Recent Papers

Sex-dependent VEGF expression underlies variations in human pluripotent stem cell to endothelial progenitor differentiation

Lauren N. Randolph, Xiaoping Bao, Michael Oddo, Xiaojun Lance Lian, 2019, Scientific reports

An Ultrasensitive Calcium Reporter System via CRISPR-Cas9-Mediated Genome Editing in Human Pluripotent Stem Cells

Yuqian Jiang, Yuxiao Zhou, Xiaoping Bao, Chuanxin Chen, Lauren N. Randolph, Jing Du, Xiaojun Lance Lian, 2018, iScience on p. 27-35

Human ISL1 <sup>+</sup> Ventricular Progenitors Self-Assemble into an In Vivo Functional Heart Patch and Preserve Cardiac Function Post Infarction

Kylie S. Foo, Miia L. Lehtinen, Chuen Yan Leung, Xiaojun Lian, Jiejia Xu, Wendy Keung, Lin Geng, Terje R.S. Kolstad, Sebastian Thams, Andy On tik Wong, Nicodemus Wong, Kristine Bylund, Chikai Zhou, Xiaobing He, Shao Bo Jin, Jonathan Clarke, Urban Lendahl, Ronald A. Li, William E. Louch, Kenneth R. Chien, 2018, Molecular Therapy on p. 1644-1659

Human Beta Cells Generated from Pluripotent Stem Cells or Cellular Reprogramming for Curing Diabetes

Lauren N. Randolph, Agamoni Bhattacharyya, Xiaojun Lian, 2018, Regenerative Engineering and Translational Medicine

An all-in-one, Tet-On 3G inducible PiggyBac system for human pluripotent stem cells and derivatives

Lauren N. Randolph, Xiaoping Bao, Chikai Zhou, Xiaojun Lian, 2017, Scientific Reports

Directed differentiation and long-term maintenance of epicardial cells derived from human pluripotent stem cells under fully defined conditions

Xiaoping Bao, Xiaojun Lian, Tongcheng Qian, Vijesh J. Bhute, Tianxiao Han, Sean P. Palecek, 2017, Nature Protocols on p. 1890-1900

Long-term self-renewing human epicardial cells generated from pluripotent stem cells under defined xeno-free conditions

Xiaoping Bao, Xiaojun Lian, Timothy A. Hacker, Eric G. Schmuck, Tongcheng Qian, Vijesh J. Bhute, Tianxiao Han, Mengxuan Shi, Lauren Drowley, Alleyn T. Plowright, Qing Dong Wang, Marie Jose Goumans, Sean P. Palecek, 2017, Nature Biomedical Engineering

Loss of CSL Unlocks a Hypoxic Response and Enhanced Tumor Growth Potential in Breast Cancer Cells

Eike Benjamin Braune, Yat Long Tsoi, Yee Peng Phoon, Sebastian Landor, Helena Silva Cascales, Daniel Ramsköld, Qiaolin Deng, Arne Lindqvist, Xiaojun Lian, Cecilia Sahlgren, Shao Bo Jin, Urban Lendahl, 2016, Stem Cell Reports on p. 643-651

Endothelin-1 supports clonal derivation and expansion of cardiovascular progenitors derived from human embryonic stem cells

Boon Seng Soh, Shi Yan Ng, Hao Wu, Kristina Buac, Joo Hye C. Park, Xiaojun Lian, Jiejia Xu, Kylie S. Foo, Ulrika Felldin, Xiaobing He, Massimo Nichane, Henry Yang, Lei Bu, Ronald A. Li, Bing Lim, Kenneth R. Chien, 2016, Nature communications

Chemically-defined albumin-free differentiation of human pluripotent stem cells to endothelial progenitor cells

Xiaoping Bao, Xiaojun Lian, Kaitlin K. Dunn, Mengxuan Shi, Tianxiao Han, Tongcheng Qian, Vijesh J. Bhute, Scott G. Canfield, Sean P. Palecek, 2015, Stem Cell Research on p. 122-129

Most-Cited Papers

Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling

Xiaojun Lian, Cheston Hsiao, Gisela Wilson, Kexian Zhu, Laurie B. Hazeltine, Samira M. Azarin, Kunil K. Raval, Jianhua Zhang, Timothy J. Kamp, Sean P. Palecek, 2012, Proceedings of the National Academy of Sciences of the United States of America on p. E1848-E1857

Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt/β-catenin signaling under fully defined conditions

Xiaojun Lian, Jianhua Zhang, Samira M. Azarin, Kexian Zhu, Laurie B. Hazeltine, Xiaoping Bao, Cheston Hsiao, Timothy J. Kamp, Sean P. Palecek, 2013, Nature Protocols on p. 162-175

Effects of substrate mechanics on contractility of cardiomyocytes generated from human pluripotent stem cells

Laurie B. Hazeltine, Chelsey S. Simmons, Max R. Salick, Xiaojun Lian, Mehmet G. Badur, Wenqing Han, Stephanie M. Delgado, Tetsuro Wakatsuki, Wendy C. Crone, Beth L. Pruitt, Sean P. Palecek, 2012, International Journal of Cell Biology

Temporal impact of substrate mechanics on differentiation of human embryonic stem cells to cardiomyocytes

Laurie B. Hazeltine, Mehmet G. Badur, Xiaojun Lian, Amritava Das, Wenqing Han, Sean P. Palecek, 2014, Acta Biomaterialia on p. 604-612

Chemically-defined albumin-free differentiation of human pluripotent stem cells to endothelial progenitor cells

Xiaoping Bao, Xiaojun Lian, Kaitlin K. Dunn, Mengxuan Shi, Tianxiao Han, Tongcheng Qian, Vijesh J. Bhute, Scott G. Canfield, Sean P. Palecek, 2015, Stem Cell Research on p. 122-129

Insulin inhibits cardiac mesoderm, not mesendoderm, formation during cardiac differentiation of human pluripotent stem cells and modulation of canonical wnt signaling can rescue this inhibition

Xiaojun Lian, Jianhua Zhang, Kexian Zhu, Timothy J. Kamp, Sean P. Palecek, 2013, STEM CELLS on p. 447-457

Properties of resistant cells generated from lung cancer cell lines treated with EGFR inhibitors

Gargi Ghosh, Xiaojun Lian, Stephen J. Kron, Sean P. Palecek, 2012, BMC Cancer

Long-term self-renewing human epicardial cells generated from pluripotent stem cells under defined xeno-free conditions

Xiaoping Bao, Xiaojun Lian, Timothy A. Hacker, Eric G. Schmuck, Tongcheng Qian, Vijesh J. Bhute, Tianxiao Han, Mengxuan Shi, Lauren Drowley, Alleyn T. Plowright, Qing Dong Wang, Marie Jose Goumans, Sean P. Palecek, 2017, Nature Biomedical Engineering

Loss of CSL Unlocks a Hypoxic Response and Enhanced Tumor Growth Potential in Breast Cancer Cells

Eike Benjamin Braune, Yat Long Tsoi, Yee Peng Phoon, Sebastian Landor, Helena Silva Cascales, Daniel Ramsköld, Qiaolin Deng, Arne Lindqvist, Xiaojun Lian, Cecilia Sahlgren, Shao Bo Jin, Urban Lendahl, 2016, Stem Cell Reports on p. 643-651

Endothelin-1 supports clonal derivation and expansion of cardiovascular progenitors derived from human embryonic stem cells

Boon Seng Soh, Shi Yan Ng, Hao Wu, Kristina Buac, Joo Hye C. Park, Xiaojun Lian, Jiejia Xu, Kylie S. Foo, Ulrika Felldin, Xiaobing He, Massimo Nichane, Henry Yang, Lei Bu, Ronald A. Li, Bing Lim, Kenneth R. Chien, 2016, Nature communications