Xiaojun Lian

Assistant Professor of Biomedical Engineering

Xiaojun Lian

Research Summary

Human Stem Cell Engineering; Genome Editing via CRISPR-Cas9; Epigenome Editing and Epigenetics.

Huck Affiliations

Links

Publication Tags

Pluripotent Stem Cells Stem Cells Catenins Cardiac Myocytes Beta Catenin Mechanics Cells Modulation Nanoparticles Substrates Endothelial Cells Intercellular Signaling Peptides And Proteins Clustered Regularly Interspaced Short Palindromic Repeats Molecules T Cells Nanopores Curing Chimeric Antigen Receptors Dna Interleukin 13 Medical Problems Human Embryonic Stem Cells Insulin Heart Therapeutics

Most Recent Papers

High-affinity mutant Interleukin-13 targeted CAR T cells enhance delivery of clickable biodegradable fluorescent nanoparticles to glioblastoma

Gloria B. Kim, Virginia Aragon-Sanabria, Lauren Randolph, Hali Jiang, Joshua A. Reynolds, Becky S. Webb, Achuthamangalam Madhankumar, Xiaojun Lian, James R. Connor, Jian Yang, Cheng Dong, 2020, Bioactive Materials on p. 624-635

Fluorescent indicators for continuous and lineage-specific reporting of cell-cycle phases in human pluripotent stem cells

Yun Chang, Peter B. Hellwarth, Lauren N. Randolph, Yufei Sun, Yuxian Xing, Wuqiang Zhu, Xiaojun Lance Lian, Xiaoping Bao, 2020, Biotechnology and Bioengineering on p. 2177-2186

Sequence-specific recognition of HIV-1 DNA with solid-state CRISPR-Cas12a-assisted nanopores (SCAN)

Reza Nouri, Yuqian Jiang, Xiaojun Lance Lian, Weihua Guan, 2020, ACS Sensors on p. 1273-1280

Heart regeneration with human pluripotent stem cells: Prospects and challenges.

Yuqian Jiang, Xiaojun Lian, 2020, Bioactive materials on p. 74-81

Sex-dependent VEGF expression underlies variations in human pluripotent stem cell to endothelial progenitor differentiation

Lauren N. Randolph, Xiaoping Bao, Michael Oddo, Xiaojun Lance Lian, 2019, Scientific Reports on p. 16696

An Ultrasensitive Calcium Reporter System via CRISPR-Cas9-Mediated Genome Editing in Human Pluripotent Stem Cells

Yuqian Jiang, Yuxiao Zhou, Xiaoping Bao, Chuanxin Chen, Lauren N. Randolph, Jing Du, Xiaojun Lance Lian, 2018, iScience on p. 27-35

Human ISL1 <sup>+</sup> Ventricular Progenitors Self-Assemble into an In Vivo Functional Heart Patch and Preserve Cardiac Function Post Infarction

Kylie S. Foo, Miia L. Lehtinen, Chuen Yan Leung, Xiaojun Lian, Jiejia Xu, Wendy Keung, Lin Geng, Terje R.S. Kolstad, Sebastian Thams, Andy On tik Wong, Nicodemus Wong, Kristine Bylund, Chikai Zhou, Xiaobing He, Shao Bo Jin, Jonathan Clarke, Urban Lendahl, Ronald A. Li, William E. Louch, Kenneth R. Chien, 2018, Molecular Therapy on p. 1644-1659

Human beta cells generated from pluripotent stem cells or cellular reprogramming for curing diabetes

Lauren N. Randolph, Agamoni Bhattacharyya, Xiaojun Lian, 2018, Regenerative Engineering and Translational Medicine

An all-in-one, Tet-On 3G inducible PiggyBac system for human pluripotent stem cells and derivatives

Lauren N. Randolph, Xiaoping Bao, Chikai Zhou, Xiaojun Lian, 2017, Scientific Reports on p. 1549

Stem Cell Engineering and Differentiation for Disease Modeling and Cell-based Therapies

Lauren Randolph, Yuqian Jiang, Xiaojun Lian, 2017, AIMS Cell and Tissue Engineering on p. 140-157

Most-Cited Papers

Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling

Xiaojun Lian, Cheston Hsiao, Gisela Wilson, Kexian Zhu, Laurie B. Hazeltine, Samira M. Azarin, Kunil K. Raval, Jianhua Zhang, Timothy J. Kamp, Sean P. Palecek, 2012, Proceedings of the National Academy of Sciences of the United States of America on p. E1848-E1857

Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt/β-catenin signaling under fully defined conditions

Xiaojun Lian, Jianhua Zhang, Samira M. Azarin, Kexian Zhu, Laurie B. Hazeltine, Xiaoping Bao, Cheston Hsiao, Timothy J. Kamp, Sean P. Palecek, 2013, Nature Protocols on p. 162-175

Extracellular matrix promotes highly efficient cardiac differentiation of human pluripotent stem cells

Jianhua Zhang, Matthew Klos, Gisela F. Wilson, Amanda M. Herman, Xiaojun Lian, Kunil K. Raval, Matthew R. Barron, Luqia Hou, Andrew G. Soerens, Junying Yu, Sean P. Palecek, Gary E. Lyons, James A. Thomson, Todd J. Herron, José Jalife, Timothy J. Kamp, 2012, Circulation Research on p. 1125-1136

Efficient differentiation of human pluripotent stem cells to endothelial progenitors via small-molecule activation of WNT signaling

Xiaojun Lian, Xiaoping Bao, Abraham Al-Ahmad, Jialu Liu, Yue Wu, Wentao Dong, Kaitlin K. Dunn, Eric V. Shusta, Sean P. Palecek, 2014, Stem Cell Reports on p. 804-816

Effects of substrate mechanics on contractility of cardiomyocytes generated from human pluripotent stem cells

Laurie B. Hazeltine, Chelsey S. Simmons, Max R. Salick, Xiaojun Lian, Mehmet G. Badur, Wenqing Han, Stephanie M. Delgado, Tetsuro Wakatsuki, Wendy C. Crone, Beth L. Pruitt, Sean P. Palecek, 2012, International Journal of Cell Biology

Modulation of Wnt/β-catenin signaling in human embryonic stem cells using a 3-D microwell array

Samira M. Azarin, Xiaojun Lian, Elise A. Larson, Heidi M. Popelka, Juan J. de Pablo, Sean P. Palecek, 2012, Biomaterials on p. 2041-2049

Chemically-defined albumin-free differentiation of human pluripotent stem cells to endothelial progenitor cells

Xiaoping Bao, Xiaojun Lian, Kaitlin K. Dunn, Mengxuan Shi, Tianxiao Han, Tongcheng Qian, Vijesh J. Bhute, Scott G. Canfield, Sean P. Palecek, 2015, Stem Cell Research on p. 122-129

Temporal impact of substrate mechanics on differentiation of human embryonic stem cells to cardiomyocytes

Laurie B. Hazeltine, Mehmet G. Badur, Xiaojun Lian, Amritava Das, Wenqing Han, Sean P. Palecek, 2014, Acta Biomaterialia on p. 604-612

Insulin inhibits cardiac mesoderm, not mesendoderm, formation during cardiac differentiation of human pluripotent stem cells and modulation of canonical wnt signaling can rescue this inhibition

Xiaojun Lian, Jianhua Zhang, Kexian Zhu, Timothy J. Kamp, Sean P. Palecek, 2013, Stem Cells on p. 447-457

Long-term self-renewing human epicardial cells generated from pluripotent stem cells under defined xeno-free conditions

Xiaoping Bao, Xiaojun Lian, Timothy A. Hacker, Eric G. Schmuck, Tongcheng Qian, Vijesh J. Bhute, Tianxiao Han, Mengxuan Shi, Lauren Drowley, Alleyn T. Plowright, Qing Dong Wang, Marie Jose Goumans, Sean P. Palecek, 2017, Nature Biomedical Engineering