Xiaojun Lian
Associate Professor of Biomedical Engineering
-
W342 Millennium Science Complex
University Park, PA - xul34@psu.edu
- 814-865-8093
Research Summary
Human Stem Cell Engineering; Genome Editing via CRISPR-Cas9; Epigenome Editing and Epigenetics.
Huck Affiliations
Links
Publication Tags
Pluripotent Stem Cells Stem Cells Cardiac Myocytes Catenins Beta Catenin Mechanics Modulation Nanoparticles Endothelial Cells Cells Glucose Drug Substrates Intercellular Signaling Peptides And Proteins Therapeutics Rna Application Genes Graphene Interleukin 13 Chimeric Antigen Receptors Lasers T Cells Human Embryonic Stem Cells MoleculesMost Recent Papers
Chemically-defined generation of human hemogenic endothelium and definitive hematopoietic progenitor cells
Yun Chang, Ramizah Syahirah, Stephanie N. Oprescu, Xuepeng Wang, Juhyung Jung, Scott H. Cooper, Sandra Torregrosa-Allen, Bennett D. Elzey, Alan Y. Hsu, Lauren N. Randolph, Yufei Sun, Shihuan Kuang, Hal E. Broxmeyer, Qing Deng, Xiaojun Lian, Xiaoping Bao, 2022, Biomaterials
Robust genome and RNA editing via CRISPR nucleases in PiggyBac systems
Yuqian Jiang, Rachel Catherine Hoenisch, Yun Chang, Xiaoping Bao, Craig E. Cameron, Xiaojun Lance Lian, 2022, Bioactive Materials on p. 313-320
A dual cardiomyocyte reporter model derived from human pluripotent stem cells
Yuqian Jiang, Xiaoping Bao, Xiaojun Lance Lian, 2021, Stem Cell Research and Therapy
Laser-induced graphene non-enzymatic glucose sensors for on-body measurements
Jia Zhu, Shangbin Liu, Zhihui Hu, Xianzhe Zhang, Ning Yi, Kairui Tang, Michael Gregory Dexheimer, Xiaojun Lian, Qing Wang, Jian Yang, Jennifer Gray, Huanyu Cheng, 2021, Biosensors and Bioelectronics
Detection of SARS-CoV-2 with Solid-State CRISPR-Cas12a-Assisted Nanopores
Reza Nouri, Yuqian Jiang, Zifan Tang, Xiaojun Lance Lian, Weihua Guan, 2021, Nano Letters on p. 8393-8400
Generation of pancreatic progenitors from human pluripotent stem cells by small molecules
Yuqian Jiang, Chuanxin Chen, Lauren N. Randolph, Songtao Ye, Xin Zhang, Xiaoping Bao, Xiaojun Lance Lian, 2021, Stem Cell Reports on p. 2395-2409
Optogenetic-mediated cardiovascular differentiation and patterning of human pluripotent stem cells
Peter B. Hellwarth, Yun Chang, Arundhati Das, Po Yu Liang, Xiaojun Lian, Nicole A. Repina, Xiaoping Bao, 2021, Advanced Genetics
Erratum
Kylie S. Foo, Miia L. Lehtinen, Chuen Yan Leung, Xiaojun Lian, Jiejia Xu, Wendy Keung, Lin Geng, Terje R.S. Kolstad, Sebastian Thams, Andy On tik Wong, Nicodemus Wong, Kristine Bylund, Chikai Zhou, Xiaobing He, Shao Bo Jin, Jonathan Clarke, Urban Lendahl, Ronald A. Li, William E. Louch, Kenneth R. Chien, 2021, Molecular Therapy on p. 409
High-affinity mutant Interleukin-13 targeted CAR T cells enhance delivery of clickable biodegradable fluorescent nanoparticles to glioblastoma
Gloria B. Kim, Virginia Aragon-Sanabria, Lauren Randolph, Hali Jiang, Joshua A. Reynolds, Becky S. Webb, Achuthamangalam Madhankumar, Xiaojun Lian, James R. Connor, Jian Yang, Cheng Dong, 2020, Bioactive Materials on p. 624-635
Fluorescent indicators for continuous and lineage-specific reporting of cell-cycle phases in human pluripotent stem cells
Yun Chang, Peter B. Hellwarth, Lauren N. Randolph, Yufei Sun, Yuxian Xing, Wuqiang Zhu, Xiaojun Lance Lian, Xiaoping Bao, 2020, Biotechnology and Bioengineering on p. 2177-2186
Most-Cited Papers
Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling
Xiaojun Lian, Cheston Hsiao, Gisela Wilson, Kexian Zhu, Laurie B. Hazeltine, Samira M. Azarin, Kunil K. Raval, Jianhua Zhang, Timothy J. Kamp, Sean P. Palecek, 2012, Proceedings of the National Academy of Sciences of the United States of America on p. E1848-E1857
Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt/β-catenin signaling under fully defined conditions
Xiaojun Lian, Jianhua Zhang, Samira M. Azarin, Kexian Zhu, Laurie B. Hazeltine, Xiaoping Bao, Cheston Hsiao, Timothy J. Kamp, Sean P. Palecek, 2013, Nature Protocols on p. 162-175
Extracellular matrix promotes highly efficient cardiac differentiation of human pluripotent stem cells
Jianhua Zhang, Matthew Klos, Gisela F. Wilson, Amanda M. Herman, Xiaojun Lian, Kunil K. Raval, Matthew R. Barron, Luqia Hou, Andrew G. Soerens, Junying Yu, Sean P. Palecek, Gary E. Lyons, James A. Thomson, Todd J. Herron, José Jalife, Timothy J. Kamp, 2012, Circulation Research on p. 1125-1136
Efficient differentiation of human pluripotent stem cells to endothelial progenitors via small-molecule activation of WNT signaling
Xiaojun Lian, Xiaoping Bao, Abraham Al-Ahmad, Jialu Liu, Yue Wu, Wentao Dong, Kaitlin K. Dunn, Eric V. Shusta, Sean P. Palecek, 2014, Stem Cell Reports on p. 804-816
Effects of substrate mechanics on contractility of cardiomyocytes generated from human pluripotent stem cells
Laurie B. Hazeltine, Chelsey S. Simmons, Max R. Salick, Xiaojun Lian, Mehmet G. Badur, Wenqing Han, Stephanie M. Delgado, Tetsuro Wakatsuki, Wendy C. Crone, Beth L. Pruitt, Sean P. Palecek, 2012, International Journal of Cell Biology
Chemically defined, albumin-free human cardiomyocyte generation
Xiaojun Lian, Xiaoping Bao, Misha Zilberter, Mattias Westman, André Fisahn, Cheston Hsiao, Laurie B. Hazeltine, Kaitlin K. Dunn, Timothy J. Kamp, Sean P. Palecek, 2015, Nature Methods on p. 595-596
Long-term self-renewing human epicardial cells generated from pluripotent stem cells under defined xeno-free conditions
Xiaoping Bao, Xiaojun Lian, Timothy A. Hacker, Eric G. Schmuck, Tongcheng Qian, Vijesh J. Bhute, Tianxiao Han, Mengxuan Shi, Lauren Drowley, Alleyn T. Plowright, Qing Dong Wang, Marie Jose Goumans, Sean P. Palecek, 2017, Nature Biomedical Engineering
Modulation of Wnt/β-catenin signaling in human embryonic stem cells using a 3-D microwell array
Samira M. Azarin, Xiaojun Lian, Elise A. Larson, Heidi M. Popelka, Juan J. de Pablo, Sean P. Palecek, 2012, Biomaterials on p. 2041-2049
Chemically-defined albumin-free differentiation of human pluripotent stem cells to endothelial progenitor cells
Xiaoping Bao, Xiaojun Lian, Kaitlin K. Dunn, Mengxuan Shi, Tianxiao Han, Tongcheng Qian, Vijesh J. Bhute, Scott G. Canfield, Sean P. Palecek, 2015, Stem Cell Research on p. 122-129
Temporal impact of substrate mechanics on differentiation of human embryonic stem cells to cardiomyocytes
Laurie B. Hazeltine, Mehmet G. Badur, Xiaojun Lian, Amritava Das, Wenqing Han, Sean P. Palecek, 2014, Acta Biomaterialia on p. 604-612
News Articles Featuring Xiaojun Lian
Mar 07, 2022
Studying diseases with better delivery of gene-editing tools
Using gene-editing tools with stem cells can be challenging because their delivery into cells can be inefficient, time-consuming, or expensive. A Penn State-led team of interdisciplinary researchers has developed a method that improves the lifespan and efficiency of CRISPR gene-editing tools after delivery.
Full Article
Aug 26, 2021
Researchers use stem cells to make insulin-producing pancreatic beta cells
The human body can be genetically inclined to attack its own cells, destroying the beta cells in the pancreas that make insulin, which helps convert sugar into energy. Called Type 1 diabetes, this disorder can occur at any age and can be fatal if not carefully managed with insulin shots or an insulin pump to balance the body’s sugar levels.
Full Article
Sep 01, 2020
Biomedical engineering graduate student receives Blue Flame Award
Lauren Randolph, a graduate research assistant in biomedical engineering at Penn State, has received the Blue Flame Award, given by Addgene, a non-profit plasmid repository. Addgene presents the award to researchers with at least one plasmid deposited at Addgene that has been distributed to other researchers more than 100 times.
Full Article
May 28, 2020
NSF CAREER grant recipient offers potential boost for stem cell therapy
Xiaojun “Lance” Lian, assistant professor of biomedical engineering at Penn State, has received a $500,000, five-year Early Career Development Program (CAREER) grant from the National Science Foundation (NSF).
Full Article
Dec 20, 2019
Penn State researcher receives a Rising Star Award in biomedical engineering
Xiaojun “Lance” Lian, assistant professor of biomedical engineering at Penn State, has been named one of the 2020 Rising Star Award recipients in stem cell engineering by the Biomedical Engineering Society’s (BMES) Cellular and Molecular Bioengineering Special Interest Group (CMBE SIG).
Full Article