Xiaojun Lian
Assistant Professor of Biomedical Engineering
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W342 Millennium Science Complex
University Park, PA - xul34@psu.edu
- 814-865-8093
Research Summary
Human Stem Cell Engineering; Genome Editing via CRISPR-Cas9; Epigenome Editing and Epigenetics.
Huck Affiliations
Links
Publication Tags
Pluripotent Stem Cells Stem Cells Catenins Cardiac Myocytes Beta Catenin Mechanics Cells Modulation Nanoparticles Substrates Endothelial Cells Intercellular Signaling Peptides And Proteins Clustered Regularly Interspaced Short Palindromic Repeats Molecules T Cells Nanopores Curing Chimeric Antigen Receptors Dna Interleukin 13 Medical Problems Human Embryonic Stem Cells Insulin Heart TherapeuticsMost Recent Papers
High-affinity mutant Interleukin-13 targeted CAR T cells enhance delivery of clickable biodegradable fluorescent nanoparticles to glioblastoma
Gloria B. Kim, Virginia Aragon-Sanabria, Lauren Randolph, Hali Jiang, Joshua A. Reynolds, Becky S. Webb, Achuthamangalam Madhankumar, Xiaojun Lian, James R. Connor, Jian Yang, Cheng Dong, 2020, Bioactive Materials on p. 624-635
Fluorescent indicators for continuous and lineage-specific reporting of cell-cycle phases in human pluripotent stem cells
Yun Chang, Peter B. Hellwarth, Lauren N. Randolph, Yufei Sun, Yuxian Xing, Wuqiang Zhu, Xiaojun Lance Lian, Xiaoping Bao, 2020, Biotechnology and Bioengineering on p. 2177-2186
Sequence-specific recognition of HIV-1 DNA with solid-state CRISPR-Cas12a-assisted nanopores (SCAN)
Reza Nouri, Yuqian Jiang, Xiaojun Lance Lian, Weihua Guan, 2020, ACS Sensors on p. 1273-1280
Heart regeneration with human pluripotent stem cells: Prospects and challenges.
Yuqian Jiang, Xiaojun Lian, 2020, Bioactive materials on p. 74-81
Sex-dependent VEGF expression underlies variations in human pluripotent stem cell to endothelial progenitor differentiation
Lauren N. Randolph, Xiaoping Bao, Michael Oddo, Xiaojun Lance Lian, 2019, Scientific Reports on p. 16696
An Ultrasensitive Calcium Reporter System via CRISPR-Cas9-Mediated Genome Editing in Human Pluripotent Stem Cells
Yuqian Jiang, Yuxiao Zhou, Xiaoping Bao, Chuanxin Chen, Lauren N. Randolph, Jing Du, Xiaojun Lance Lian, 2018, iScience on p. 27-35
Human ISL1 <sup>+</sup> Ventricular Progenitors Self-Assemble into an In Vivo Functional Heart Patch and Preserve Cardiac Function Post Infarction
Kylie S. Foo, Miia L. Lehtinen, Chuen Yan Leung, Xiaojun Lian, Jiejia Xu, Wendy Keung, Lin Geng, Terje R.S. Kolstad, Sebastian Thams, Andy On tik Wong, Nicodemus Wong, Kristine Bylund, Chikai Zhou, Xiaobing He, Shao Bo Jin, Jonathan Clarke, Urban Lendahl, Ronald A. Li, William E. Louch, Kenneth R. Chien, 2018, Molecular Therapy on p. 1644-1659
Human beta cells generated from pluripotent stem cells or cellular reprogramming for curing diabetes
Lauren N. Randolph, Agamoni Bhattacharyya, Xiaojun Lian, 2018, Regenerative Engineering and Translational Medicine
An all-in-one, Tet-On 3G inducible PiggyBac system for human pluripotent stem cells and derivatives
Lauren N. Randolph, Xiaoping Bao, Chikai Zhou, Xiaojun Lian, 2017, Scientific Reports on p. 1549
Stem Cell Engineering and Differentiation for Disease Modeling and Cell-based Therapies
Lauren Randolph, Yuqian Jiang, Xiaojun Lian, 2017, AIMS Cell and Tissue Engineering on p. 140-157
Most-Cited Papers
Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling
Xiaojun Lian, Cheston Hsiao, Gisela Wilson, Kexian Zhu, Laurie B. Hazeltine, Samira M. Azarin, Kunil K. Raval, Jianhua Zhang, Timothy J. Kamp, Sean P. Palecek, 2012, Proceedings of the National Academy of Sciences of the United States of America on p. E1848-E1857
Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt/β-catenin signaling under fully defined conditions
Xiaojun Lian, Jianhua Zhang, Samira M. Azarin, Kexian Zhu, Laurie B. Hazeltine, Xiaoping Bao, Cheston Hsiao, Timothy J. Kamp, Sean P. Palecek, 2013, Nature Protocols on p. 162-175
Extracellular matrix promotes highly efficient cardiac differentiation of human pluripotent stem cells
Jianhua Zhang, Matthew Klos, Gisela F. Wilson, Amanda M. Herman, Xiaojun Lian, Kunil K. Raval, Matthew R. Barron, Luqia Hou, Andrew G. Soerens, Junying Yu, Sean P. Palecek, Gary E. Lyons, James A. Thomson, Todd J. Herron, José Jalife, Timothy J. Kamp, 2012, Circulation Research on p. 1125-1136
Efficient differentiation of human pluripotent stem cells to endothelial progenitors via small-molecule activation of WNT signaling
Xiaojun Lian, Xiaoping Bao, Abraham Al-Ahmad, Jialu Liu, Yue Wu, Wentao Dong, Kaitlin K. Dunn, Eric V. Shusta, Sean P. Palecek, 2014, Stem Cell Reports on p. 804-816
Effects of substrate mechanics on contractility of cardiomyocytes generated from human pluripotent stem cells
Laurie B. Hazeltine, Chelsey S. Simmons, Max R. Salick, Xiaojun Lian, Mehmet G. Badur, Wenqing Han, Stephanie M. Delgado, Tetsuro Wakatsuki, Wendy C. Crone, Beth L. Pruitt, Sean P. Palecek, 2012, International Journal of Cell Biology
Modulation of Wnt/β-catenin signaling in human embryonic stem cells using a 3-D microwell array
Samira M. Azarin, Xiaojun Lian, Elise A. Larson, Heidi M. Popelka, Juan J. de Pablo, Sean P. Palecek, 2012, Biomaterials on p. 2041-2049
Chemically-defined albumin-free differentiation of human pluripotent stem cells to endothelial progenitor cells
Xiaoping Bao, Xiaojun Lian, Kaitlin K. Dunn, Mengxuan Shi, Tianxiao Han, Tongcheng Qian, Vijesh J. Bhute, Scott G. Canfield, Sean P. Palecek, 2015, Stem Cell Research on p. 122-129
Temporal impact of substrate mechanics on differentiation of human embryonic stem cells to cardiomyocytes
Laurie B. Hazeltine, Mehmet G. Badur, Xiaojun Lian, Amritava Das, Wenqing Han, Sean P. Palecek, 2014, Acta Biomaterialia on p. 604-612
Insulin inhibits cardiac mesoderm, not mesendoderm, formation during cardiac differentiation of human pluripotent stem cells and modulation of canonical wnt signaling can rescue this inhibition
Xiaojun Lian, Jianhua Zhang, Kexian Zhu, Timothy J. Kamp, Sean P. Palecek, 2013, Stem Cells on p. 447-457
Long-term self-renewing human epicardial cells generated from pluripotent stem cells under defined xeno-free conditions
Xiaoping Bao, Xiaojun Lian, Timothy A. Hacker, Eric G. Schmuck, Tongcheng Qian, Vijesh J. Bhute, Tianxiao Han, Mengxuan Shi, Lauren Drowley, Alleyn T. Plowright, Qing Dong Wang, Marie Jose Goumans, Sean P. Palecek, 2017, Nature Biomedical Engineering
News Articles Featuring Xiaojun Lian
Sep 01, 2020
Biomedical engineering graduate student receives Blue Flame Award
Lauren Randolph, a graduate research assistant in biomedical engineering at Penn State, has received the Blue Flame Award, given by Addgene, a non-profit plasmid repository. Addgene presents the award to researchers with at least one plasmid deposited at Addgene that has been distributed to other researchers more than 100 times.
Full Article
May 28, 2020
NSF CAREER grant recipient offers potential boost for stem cell therapy
Xiaojun “Lance” Lian, assistant professor of biomedical engineering at Penn State, has received a $500,000, five-year Early Career Development Program (CAREER) grant from the National Science Foundation (NSF).
Full Article
Dec 20, 2019
Penn State researcher receives a Rising Star Award in biomedical engineering
Xiaojun “Lance” Lian, assistant professor of biomedical engineering at Penn State, has been named one of the 2020 Rising Star Award recipients in stem cell engineering by the Biomedical Engineering Society’s (BMES) Cellular and Molecular Bioengineering Special Interest Group (CMBE SIG).
Full Article