Xiaojun Lian

Associate Professor of Biomedical Engineering

Xiaojun Lian

Research Summary

Human Stem Cell Engineering; Genome Editing via CRISPR-Cas9; Epigenome Editing and Epigenetics.

Huck Affiliations

Links

Publication Tags

Stem Cells Pluripotent Stem Cells Cardiac Myocytes Catenins Heart Beta Catenin Mechanics Endothelial Cells Modulation Nanoparticles Cells Substrates Therapeutics Application Intercellular Signaling Peptides And Proteins Clustered Regularly Interspaced Short Palindromic Repeats Molecules Human Embryonic Stem Cells Infarction Dna Interleukin 13 Chimeric Antigen Receptors Nanopores T Cells Drug

Most Recent Papers

A dual cardiomyocyte reporter model derived from human pluripotent stem cells

Yuqian Jiang, Xiaoping Bao, Xiaojun Lance Lian, 2021, Stem Cell Research and Therapy

Erratum

Kylie S. Foo, Miia L. Lehtinen, Chuen Yan Leung, Xiaojun Lian, Jiejia Xu, Wendy Keung, Lin Geng, Terje R.S. Kolstad, Sebastian Thams, Andy On tik Wong, Nicodemus Wong, Kristine Bylund, Chikai Zhou, Xiaobing He, Shao Bo Jin, Jonathan Clarke, Urban Lendahl, Ronald A. Li, William E. Louch, Kenneth R. Chien, 2021, Molecular Therapy on p. 409

High-affinity mutant Interleukin-13 targeted CAR T cells enhance delivery of clickable biodegradable fluorescent nanoparticles to glioblastoma

Gloria B. Kim, Virginia Aragon-Sanabria, Lauren Randolph, Hali Jiang, Joshua A. Reynolds, Becky S. Webb, Achuthamangalam Madhankumar, Xiaojun Lian, James R. Connor, Jian Yang, Cheng Dong, 2020, Bioactive Materials on p. 624-635

Fluorescent indicators for continuous and lineage-specific reporting of cell-cycle phases in human pluripotent stem cells

Yun Chang, Peter B. Hellwarth, Lauren N. Randolph, Yufei Sun, Yuxian Xing, Wuqiang Zhu, Xiaojun Lance Lian, Xiaoping Bao, 2020, Biotechnology and Bioengineering on p. 2177-2186

Sequence-specific recognition of HIV-1 DNA with solid-state CRISPR-Cas12a-assisted nanopores (SCAN)

Reza Nouri, Yuqian Jiang, Xiaojun Lance Lian, Weihua Guan, 2020, ACS Sensors on p. 1273-1280

Heart regeneration with human pluripotent stem cells

Yuqian Jiang, Xiaojun Lance Lian, 2020, Bioactive Materials on p. 74-81

Sex-dependent VEGF expression underlies variations in human pluripotent stem cell to endothelial progenitor differentiation

Lauren N. Randolph, Xiaoping Bao, Michael Oddo, Xiaojun Lance Lian, 2019, Scientific Reports on p. 16696

Beyond Purple Hearts

Lauren N. Randolph, Xiaojun Lance Lian, 2019, Cell Stem Cell on p. 675-677

An Ultrasensitive Calcium Reporter System via CRISPR-Cas9-Mediated Genome Editing in Human Pluripotent Stem Cells

Yuqian Jiang, Yuxiao Zhou, Xiaoping Bao, Chuanxin Chen, Lauren N. Randolph, Jing Du, Xiaojun Lance Lian, 2018, iScience on p. 27-35

Human ISL1 <sup>+</sup> Ventricular Progenitors Self-Assemble into an In Vivo Functional Heart Patch and Preserve Cardiac Function Post Infarction

Kylie S. Foo, Miia L. Lehtinen, Chuen Yan Leung, Xiaojun Lian, Jiejia Xu, Wendy Keung, Lin Geng, Terje R.S. Kolstad, Sebastian Thams, Andy On tik Wong, Nicodemus Wong, Kristine Bylund, Chikai Zhou, Xiaobing He, Shao Bo Jin, Jonathan Clarke, Urban Lendahl, Ronald A. Li, William E. Louch, Kenneth R. Chien, 2018, Molecular Therapy on p. 1644-1659

Most-Cited Papers

Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling

Xiaojun Lian, Cheston Hsiao, Gisela Wilson, Kexian Zhu, Laurie B. Hazeltine, Samira M. Azarin, Kunil K. Raval, Jianhua Zhang, Timothy J. Kamp, Sean P. Palecek, 2012, Proceedings of the National Academy of Sciences of the United States of America on p. E1848-E1857

Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt/β-catenin signaling under fully defined conditions

Xiaojun Lian, Jianhua Zhang, Samira M. Azarin, Kexian Zhu, Laurie B. Hazeltine, Xiaoping Bao, Cheston Hsiao, Timothy J. Kamp, Sean P. Palecek, 2013, Nature Protocols on p. 162-175

Extracellular matrix promotes highly efficient cardiac differentiation of human pluripotent stem cells

Jianhua Zhang, Matthew Klos, Gisela F. Wilson, Amanda M. Herman, Xiaojun Lian, Kunil K. Raval, Matthew R. Barron, Luqia Hou, Andrew G. Soerens, Junying Yu, Sean P. Palecek, Gary E. Lyons, James A. Thomson, Todd J. Herron, José Jalife, Timothy J. Kamp, 2012, Circulation Research on p. 1125-1136

Efficient differentiation of human pluripotent stem cells to endothelial progenitors via small-molecule activation of WNT signaling

Xiaojun Lian, Xiaoping Bao, Abraham Al-Ahmad, Jialu Liu, Yue Wu, Wentao Dong, Kaitlin K. Dunn, Eric V. Shusta, Sean P. Palecek, 2014, Stem Cell Reports on p. 804-816

Effects of substrate mechanics on contractility of cardiomyocytes generated from human pluripotent stem cells

Laurie B. Hazeltine, Chelsey S. Simmons, Max R. Salick, Xiaojun Lian, Mehmet G. Badur, Wenqing Han, Stephanie M. Delgado, Tetsuro Wakatsuki, Wendy C. Crone, Beth L. Pruitt, Sean P. Palecek, 2012, International Journal of Cell Biology

Chemically defined, albumin-free human cardiomyocyte generation

Xiaojun Lian, Xiaoping Bao, Misha Zilberter, Mattias Westman, André Fisahn, Cheston Hsiao, Laurie B. Hazeltine, Kaitlin K. Dunn, Timothy J. Kamp, Sean P. Palecek, 2015, Nature Methods on p. 595-596

Modulation of Wnt/β-catenin signaling in human embryonic stem cells using a 3-D microwell array

Samira M. Azarin, Xiaojun Lian, Elise A. Larson, Heidi M. Popelka, Juan J. de Pablo, Sean P. Palecek, 2012, Biomaterials on p. 2041-2049

Chemically-defined albumin-free differentiation of human pluripotent stem cells to endothelial progenitor cells

Xiaoping Bao, Xiaojun Lian, Kaitlin K. Dunn, Mengxuan Shi, Tianxiao Han, Tongcheng Qian, Vijesh J. Bhute, Scott G. Canfield, Sean P. Palecek, 2015, Stem Cell Research on p. 122-129

Temporal impact of substrate mechanics on differentiation of human embryonic stem cells to cardiomyocytes

Laurie B. Hazeltine, Mehmet G. Badur, Xiaojun Lian, Amritava Das, Wenqing Han, Sean P. Palecek, 2014, Acta Biomaterialia on p. 604-612

Long-term self-renewing human epicardial cells generated from pluripotent stem cells under defined xeno-free conditions

Xiaoping Bao, Xiaojun Lian, Timothy A. Hacker, Eric G. Schmuck, Tongcheng Qian, Vijesh J. Bhute, Tianxiao Han, Mengxuan Shi, Lauren Drowley, Alleyn T. Plowright, Qing Dong Wang, Marie Jose Goumans, Sean P. Palecek, 2017, Nature Biomedical Engineering

News Articles Featuring Xiaojun Lian

Aug 26, 2021

Researchers use stem cells to make insulin-producing pancreatic beta cells

The human body can be genetically inclined to attack its own cells, destroying the beta cells in the pancreas that make insulin, which helps convert sugar into energy. Called Type 1 diabetes, this disorder can occur at any age and can be fatal if not carefully managed with insulin shots or an insulin pump to balance the body’s sugar levels.

Full Article

Sep 01, 2020

Biomedical engineering graduate student receives Blue Flame Award

Lauren Randolph, a graduate research assistant in biomedical engineering at Penn State, has received the Blue Flame Award, given by Addgene, a non-profit plasmid repository. Addgene presents the award to researchers with at least one plasmid deposited at Addgene that has been distributed to other researchers more than 100 times.

Full Article

May 28, 2020

NSF CAREER grant recipient offers potential boost for stem cell therapy

Xiaojun “Lance” Lian, assistant professor of biomedical engineering at Penn State, has received a $500,000, five-year Early Career Development Program (CAREER) grant from the National Science Foundation (NSF). 

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Dec 20, 2019

Penn State researcher receives a Rising Star Award in biomedical engineering

Xiaojun “Lance” Lian, assistant professor of biomedical engineering at Penn State, has been named one of the 2020 Rising Star Award recipients in stem cell engineering by the Biomedical Engineering Society’s (BMES) Cellular and Molecular Bioengineering Special Interest Group (CMBE SIG).

Full Article