Keefe Manning
Professor of Biomedical Engineering and Surgery
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530 Chemical and Biomedical Engineering
University Park, PA - kbm10@psu.edu
- 814-863-6318
Research Summary
Understanding the native cardiovascular system fluid mechanics; understanding the diseased cardiovascular system fluid mechanics, and the impact that cardiovascular prosthetics generate during and post implantation.
Huck Graduate Students
Huck Affiliations
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Publication Tags
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Blood Hydrodynamics Computational Fluid Dynamics Hemodynamics Pumps Scaffolds Equipment And Supplies Thrombosis Shear Stress Heart Valves Anisotropy Biomedical Equipment Benchmarking Inferior Vena Cava Elastomeric Valve Microfibers Tissue Pressure Hemolysis Pump Poly(Glycerol Sebacate) Velocity Measurement Polycaprolactone GeometryMost Recent Publications
Venous Thromboembolism: Review of Clinical Challenges, Biology, Assessment, Treatment, and Modeling
Connor Watson, Hicham Saaid, Vijay Vedula, Jessica Cardenas, Peter Henke, Franck Nicoud, Xiao Yu, Beverley Hunt, Keefe Manning, 2024, Ann Biomed Eng on p. 467-486
Influence of Hematocrit Level and Integrin α<sub>IIb</sub>β<sub>III</sub> Function on vWF-Mediated Platelet Adhesion and Shear-Induced Platelet Aggregation in a Sudden Expansion
Connor T. Watson, Shane C. Ward, Stefano A. Rizzo, Alberto Redaelli, Keefe B. Manning, 2024, Cellular and Molecular Bioengineering on p. 49-65
Numerical Study on the Impact of Central Venous Catheter Placement on Blood Flow in the Cavo-Atrial Junction
Boyang Su, Hannah Palahnuk, Thaddeus Harbaugh, Elias Rizk, Sprague Hazard, W Hazard, Angel Chan, Jonathan Weinsaft, J Bernstein, K Manning, J Weinsaft, Keefe B. Manning, 2024, Annals of Biomedical Engineering
Clot embolization studies and computational framework for embolization in a canonical tube model
Nicolas Tobin, Menghan Li, Gretchen Hiller, Arash Azimi, Keefe B. Manning, 2023, Scientific Reports
Effect of Hematocrit and Elevated Beat Rate on the 12cc Penn State Pediatric Ventricular Assist Device
Sailahari V. Ponnaluri, Brady L. Houtz, Emma C. Raich, Bryan C. Good, Steven Deutsch, William J. Weiss, Keefe B. Manning, 2023, ASAIO Journal on p. 1065-1073
The Accelerated Transcatheter Heart Valve Testing Environment: Loading, Motion, and Fluid Dynamics
Sailahari V. Ponnaluri, Michael S. Sacks, Keefe B. Manning, 2023, Journal of Biomechanical Engineering on p. 031005
Venous Thromboembolism: Review of Clinical Challenges, Biology, Assessment, Treatment, and Modeling
Connor Watson, Hicham Saaid, Vijay Vedula, Jessica C. Cardenas, Peter K. Henke, Franck Nicoud, Xiao Yun Xu, Beverley J. Hunt, Keefe B. Manning, 2023, Annals of Biomedical Engineering
Results of the Interlaboratory Computational Fluid Dynamics Study of the FDA Benchmark Blood Pump
Sailahari V. Ponnaluri, Prasanna Hariharan, Luke H. Herbertson, Keefe B. Manning, Richard A. Malinauskas, Brent A. Craven, 2023, Annals of Biomedical Engineering on p. 253-269
Modeling flow in an in vitro anatomical cerebrovascular model with experimental validation
Saurabh Bhardwaj, Brent A. Craven, Jacob E. Sever, Francesco Costanzo, Scott D. Simon, Keefe B. Manning, 2023, Frontiers in Medical Technology
Computational Modeling of the Penn State Fontan Circulation Assist Device
Bryan C. Good, Sailahari V. Ponnaluri, William Weiss, Keefe B. Manning, 2022, ASAIO Journal on p. 1513-1522
Most-Cited Papers
Tri-layered elastomeric scaffolds for engineering heart valve leaflets
Nafiseh Masoumi, Nasim Annabi, Alexander Assmann, Benjamin L. Larson, Jesper Hjortnaes, Neslihan Alemdar, Mahshid Kharaziha, Keefe B. Manning, John E. Mayer, Ali Khademhosseini, 2014, Biomaterials on p. 7774-7785
FDA Benchmark Medical Device Flow Models for CFD Validation
Richard A. Malinauskas, Prasanna Hariharan, Steven W. Day, Luke H. Herbertson, Martin Buesen, Ulrich Steinseifer, Kenneth I. Aycock, Bryan C. Good, Steven Deutsch, Keefe B. Manning, Brent A. Craven, 2017, ASAIO Journal on p. 150-160
Electrospun PGS: PCL Microfibers Align Human Valvular Interstitial Cells and Provide Tunable Scaffold Anisotropy
Nafiseh Masoumi, Benjamin L. Larson, Nasim Annabi, Mahshid Kharaziha, Behnam Zamanian, Kayle S. Shapero, Alexander T. Cubberley, Gulden Camci-Unal, Keefe B. Manning, John E. Mayer, Ali Khademhosseini, 2014, Advanced healthcare materials on p. 929-939
Development of a computational model for macroscopic predictions of device-induced thrombosis
Joshua O. Taylor, Richard S. Meyer, Steven Deutsch, Keefe B. Manning, 2016, Biomechanics and Modeling in Mechanobiology on p. 1713-1731
Hemodynamics in a Pediatric Ascending Aorta Using a Viscoelastic Pediatric Blood Model
Bryan C. Good, Steven Deutsch, Keefe B. Manning, 2016, Annals of Biomedical Engineering on p. 1019-1035
Science for surgeons: Understanding pump thrombogenesis in continuous-flow left ventricular assist devices
Andreas R. De Biasi, Keefe B. Manning, Arash Salemi, 2015, Journal of Thoracic and Cardiovascular Surgery on p. 667-673
Inter-Laboratory Characterization of the Velocity Field in the FDA Blood Pump Model Using Particle Image Velocimetry (PIV)
Prasanna Hariharan, Kenneth I. Aycock, Martin Buesen, Steven W. Day, Bryan C. Good, Luke H. Herbertson, Ulrich Steinseifer, Keefe B. Manning, Brent A. Craven, Richard A. Malinauskas, 2018, Cardiovascular Engineering and Technology on p. 623-640
The Importance of Hemorheology and Patient Anatomy on the Hemodynamics in the Inferior Vena Cava
Kenneth I. Aycock, Robert Lee Campbell, Frank Lynch, Keefe B. Manning, Brent A. Craven, 2016, Annals of Biomedical Engineering on p. 3568-3582
In vitro quantification of time dependent thrombus size using magnetic resonance imaging and computational simulations of thrombus surface shear stresses
Joshua O. Taylor, Kory P. Witmer, Thomas Neuberger, Brent A. Craven, Richard S. Meyer, Steven Deutsch, Keefe B. Manning, 2014, Journal of Biomechanical Engineering
A Computational method for predicting inferior vena cava filter performance on a patient-specific basis
Kenneth I. Aycock, Robert L. Campbell, Keefe B. Manning, Shankar P. Sastry, Suzanne M. Shontz, Frank C. Lynch, Brent A. Craven, 2014, Journal of Biomechanical Engineering
News Articles Featuring Keefe Manning
Jan 05, 2023
Controlled, localized delivery of blood thinner may improve blood clot treatment
Heparin has long been used as a blood thinner, or anticoagulant, for patients with blood clotting disorders or after surgery to prevent complications. But the medication remains difficult to dose correctly, potentially leading to overdosing or underdosing.
Full Article
Sep 23, 2019
Penn State researchers receive grant to explore novel method of anticoagulation
Two Penn State biomedical engineering faculty members have received a two-year, $200,000 grant from the American Heart Association (AHA) to explore potential solutions to thrombosis, or blood clot formation, a prevalent issue with blood-contacting medical devices such as heart valves, blood pumps and cardiac stents.
Full Article