The Huck Institutes of the Life Sciences

The Millennium Cafe

Hua Tian and Kristina Douglass (Penn State)

When: Tuesday, August 14, 2018 - 10:00am - August 14, 2018 - 11:00am
Where: 3rd Floor Commons at The Millennium Science Complex

Extending the Chemical Vision in Life Science by Cluster Time-of-Flight  Secondary Ion Mass Spectrometry Imaging (ToF-SIMS)”

Hua Tian   |  Penn State Department of Chemistry


Understanding the function of bio-systems (e.g., cells and tissues) and their interaction with exogenous compounds requires the ability to visualize  spatial distribution of the biomolecules (e.g., lipids, small metabolites) and compounds at subcellular resolution. However, the routine laboratory assays are largely done by bulk analysis on extraction from dissociated cells and tissues, in which the spatial distribution is lost. We have been developing cluster ToF-SIMS to map the chemistry on the frozen-hydrated biological samples with high resolution (< 1µm) and mass range up to m/z 5000. This recent development opens new opportunities for multi-omics, cell heterogeneity and disease mark and target, leading to the further understanding of disease progress and new treatment development.


Shifting Landscapes: Collaborative Archaeology in Southwest Madagascar”

Kristina Douglass  Penn State Department of Anthropology & Institutes of Energy and the Environment


Since 2011 the Morombe Archaeological Project has undertaken archaeological survey, excavation and oral history recording in the Velondriake Marine Protected Area of southwest Madagascar. The project’s aims are to investigate diachronic human-environment dynamics and refine our understanding of the region’s settlement history by leveraging multiple scientific techniques and the collective historical and socio-ecological knowledge base of Velondriake’s living communities. In this presentation I describe the outcomes of the project’s approach to integrate diverse community members and collective knowledge in all aspects of the research and promote this approach as necessary for understanding the region’s rapidly shifting landscapes. 



The Millennium Café is held every Tuesday @ 10:00 in the 3rd floor Café Commons of the Millennium Science Complex.  Stop by for freshly brewed science & coffee.