"Host-Virus Interactions: Lessons from Ebola virus"
Paul Bates (Perelman School of Medicine @ University of Pennsylvania)
Generally, research in the Bates lab focuses on viral glycoproteins and host factors that facilitate infection. Although we work with a number of different viral systems, current projects concentrate on several pathogenic viruses including filoviruses (ebolavirus and Marburgvirus) and bunyaviruses (Hantaan, Andes, Sin Nombre, La Crosse). We recently initiated research on the intrinsic antiviral factor, Tetherin, that we showed is a broadly acting antiviral factor capable of activating NFkB. Current research is examining whether Tetherin is a new innate immune pattern recognition receptor.