Noll Seminar – 10/13/17, 11:15 am - 127 Noll Laboratory
Andrew Patterson (Pennsylvania State University)
Friday 13 October
“Intestinal Epithelial Cell Receptors as Modulators of Host-Microbiota Communication,” Andrew Patterson, Ph.D., Associate Professor of Molecular Toxicology, Associate Professor of Biochemistry & Molecular Biology, Department of Veterinary and Biomedical Sciences, College of Agricultural Sciences, Pennsylvania State University, University Park, PA, 11:15 am to 12:30 pm, 127 Noll Laboratory, host: Department of Kinesiology (865-7575).
Abstract: A complex network of host receptors and microbiota within the gastrointestinal tract work in concert to process and absorb dietary nutrients, detoxify xenobiotics, and establish a homeostatic system that regulates metabolism and inflammation. Emerging evidence suggests ligand-activated transcription factors of the nuclear receptor superfamily and the basic helix-loop-helix/per-arnt-sim (PAS) family not only receive and process chemical signals derived from microbial-dependent metabolic activity, but also transmit these signals to distant organs, including the liver. For example, small intestine signaling of the farnesoid X receptor (FXR), an essential regulator of bile acid, lipid, and glucose metabolism, is modulated through gut microbiome-dependent metabolism of bile acid metabolites produced in the liver. Additionally, studies of the aryl hydrocarbon receptor (AHR), a xenobiotic sensor, have revealed microbial metabolites derived from dietary nutrients including tryptophan as critical regulators of both intestinal and hepatic inflammation. Dissection of the host-metabolite-microbiome interaction was facilitated by use of transgenic mouse models, host and microbiome sequencing, and mass spectrometry- and NMR-based metabolomics. Identification and characterization of microbial metabolites and their relationship with host receptors will provide new avenues for studying host-microbiota communication networks and identifying new therapeutics to modulate this interaction in human disease.