The Proposal
For the comprehensive exam, you will write a thesis proposal. This proposal is an overview of the work you plan to complete and the rationale for why the work is worth doing. It should include some preliminary data, along with a set of experimental aims that you plan to complete over the next few years. You can discuss the scope of your project with your adviser, but the proposal should be written entirely by you. It is an excellent opportunity to get your thoughts in order about what you really want to accomplish, and to get feedback on your plan.
If you are submitting a fellowship application close to the time of your comprehensive exam, feel free to use the format of the application. It is a great opportunity to get feedback and improve your proposal.
If you are not submitting a fellowship, I recommend using the NIH R21 grant format. It is a fairly standard, compact format. Please make sure to choose a specific format for your proposal, and follow the guidelines; this gives you practical grant-writing experience. Please also tell your committee what format you are using and why so they know what to expect and can give comments that are appropriate for the format.
Again, the default format I recommend is R21. This is a short format. Since it is compact, every word needs to be carefully selected. If you go into your exam after handing in something that is short, but not polished, your committee will think you put in minimal effort. You do not want your exam to start that way.
Formatting Guidelines
Font: Arial, Helvetica, Palatino Linotype, or Georgia 11 point or larger (I generally use Arial 11 point)
Margins: 0.5 in
Figures: Can use smaller font in legends. These should be included in the body of the proposal near where they are mentioned. In Microsoft Word, I recommend inserting the figure panel into one cell of a table and placing the legend in a cell beside or below the figure. This way the legend and figure stay together. Figures and diagrams are a great way to make complex data and ideas simple and accessible for your committee. Use them effectively.
Content and Length Guidelines
Page 1 (1-page limit): This first page should give a brief introduction to the topic of your thesis, major questions you will address, and why they are important. You will also briefly outline three aims and identify your specific question/hypothesis and how will you go about addressing it.
Pages 2-7 (6-page limit): These pages should include the following sections:
Significance - What is the problem you will address? Why is it important to work in this area? How will your work make key progress in this important field?
Innovation - How is your proposal particularly innovative?
Approach - This is the main body of the proposal. You should include your preliminary data where appropriate. For each aim, explain the key problem briefly and then describe the experimental approach you will use. Make use of diagrams. One way to structure the aims is to divide each into three parts: 1) Rationale, 2) Experimental Approach, 3) Outcomes and Alternatives. Using this structure can help remind you that you need to say why you are doing each experiment in the beginning, and at the end what you will do if it doesn’t work (alternatives) and what will be learned at the end of the studies.
References - These should be listed at the end of your proposal and are not counted as part of the page limit. Your committee will evaluate your scholarship. Part of this is making sure you know the background in your field. This means you need to include plenty of appropriate references and be familiar with their content. Use a reference manager like EndNote.
Please ask the program chair if you would like an example proposal.