Building a Neuron with Microtubules and Motors

Neuroscience

Jill Wildonger, University of Wisconsin-Madison

October 24, 2018 @ 05:00 pm to 06:00 pm

108 Wartik Lab with video to Hershey COM Room CG624F
University Park

Event Website


Neurons are functionally and structurally polarized cells, with distinct cellular projections that are specialized to receive and send signals (dendrites and axons, respectively). Axons and dendrites are essential for transmitting signals within a neuronal circuit, yet the molecular mechanisms that create these distinct structures have remained elusive. Our lab is addressing how neuronal polarity is created and maintained by focusing on the microtubule cytoskeleton, which has a dual function within cells: microtubules provide morphological structure and also serve as the major highway۝ for the transport of proteins and organelles that are integral to neuronal function. We are combining genetic, molecular, live-cell imaging and biochemical approaches to delineate the microtubule-based mechanisms that create a polarized neuron, using the developing fruit fly as a model. Reflecting the importance of the microtubule cytoskeleton in neuronal development, multiple human neurodevelopmental disorders, including classic lissencephaly, are linked to microtubule defects. One of our central goals is to identify the molecular and cellular etiology of human disorders arising from microtubule defects, and determine how changes in the microtubule cytoskeleton impact neuronal structure and function.

Contact

Melissa Rolls
mur22@psu.edu