Research Publications

Facility provides infrastructure and support for investigators to undertake single crystal X-ray structural studies. Provides instrumentation, training, and collaboration for Protein characterization, including dynamic light scattering, differential scanning calorimetry, bio-layer interferometry, and circular dichroism; Binding studies using isothermal titration calorimetry; Robotic crystallization, incubators, UV, and digital microscopes;Robotic imaging; Diffraction data collection and processing; Structure determination and analysis; Molecular modeling; Small angle X-ray scattering. Staff is available to train researchers to use equipment and to assist with project development and research.

RRID

SCR_024464

Research Publications Supported by This Facility

• RNA polymerase II CTD Ser5 phosphorylation induces competing effects of expansion and compaction.
  Cohen MR, Chen W, Dewing SM, Barr WP, Sethi KA, East RB, Onwuzulu OC, Showalter SA, Ball KA
  Biophys J. 2026 Aug 18; 125(16): 4204-4218. doi: 10.1016/j.bpj.2026.01.019. 2026 Jan 13.
• Organization of core mitochondrial replication components into multiphasic condensates.
  Yao Y, Tangade AS, Livingston Q, Mondal A, Parikh N, Mittal J, Feric M
  bioRxiv. 2026 Mar 5; (): . pii: 2026.03.03.709306. doi: 10.64898/2026.03.03.709306. 2026 Mar 5.
• Comparative analysis of single-stranded and non-canonical DNA formation in human and other ape cells with telomere-to-telomere genomes.
  Sieg J, Zeng H, Pálová H, Smeds L, Mohanty S, Lahnsteiner A, Chiaromonte F, Makova KD
  bioRxiv. 2025 Nov 4; (): . pii: 2025.11.03.686349. doi: 10.1101/2025.11.03.686349. 2025 Nov 4.
• A Piecewise Design Approach to Engineering a Miniature ACE2 Mimic to Bind SARS-CoV-2.
  Vishweshwaraiah YL, Hnath B, Wang J, Chandler M, Mukherjee A, Yennawar NH, Booker SJ, Afonin KA, Dokholyan NV
  ACS Appl Bio Mater. 2024 May 20; 7(5): 3238-3246. doi: 10.1021/acsabm.4c00222. 2024 May 3.