The Huck Institutes of the Life Sciences

Ordway lab

Rick Ordway's lab investigates molecular mechanisms of synaptic transmission.
presynaptically localized calcium channels

presynaptically localized calcium channels

In the Ordway lab we use genetic, electrophysiological and imaging approaches to investigate the in vivo molecular mechanisms of synaptic function. One model system in which we can combine these powerful approaches is the Drosophila neuromuscular junction. One way we get at physiological mechanisms operating at mature native synapses is by using temperature-sensitive paralytic mutants to acutely perturb specific gene products.