The Huck Institutes of the Life Sciences

Lai lab

In Zhi-Chun Lai's lab we study the control of tissue growth and organ size by the Hippo signaling pathway.
mats mutant

mats mutant

In the Lai lab we use Drosophila as a model system to understand how cell growth, proliferation and apoptosis are coordinated to control tissue growth and organ size during development. We also study how disruption of growth regulatory mechanisms can lead to diseases such as cancer. Our current research focuses on the Hippo tumor suppression pathway, as it is crucial for growth regulation. In particular we are focusing on the function of Mats, a kinase that is downstream of Hippo.