The Huck Institutes of the Life Sciences

MicroCal VP-capillary DSC

The VP-capillary DSC is the most sensitive, easy to use differential scanning calorimeter to study samples in solution, providing fast, accurate transition midpoint (Tm) determination and ΔH.
MicroCal VP-DSC

MicroCal VP-capillary DSC

Related information

Differential scanning calorimetry
Principles and design of differential scanning calorimetry experiments


  • Study macromolecular folding stability:
  • Effects of protein mutagenesis and engineering
  • Effects of buffer, pH, salt, additives
  • Effects of post-translational modification
  • Reversibility of unfolding, by changes in ΔH
  • Presence of multiple unfolding domains
  • Stability contributions of individual domains
  • Formation of protein complexes
  • Stability of oligonucelotides
  • Effects of lipid, nucleic acid, or other biopolymer on protein stability



  • Operating temperature range: -10°C to 130°C
  • Minimum response time (high gain): 5 seconds
  • Cell design: Tantalum 130 µl capillary type
  • Short term noise: 0.6µcal/°C
  • Baseline reliability: 1.5 µcal/°C