The Huck Institutes of the Life Sciences


Red blood cells
Research being done by Physiology graduate program faculty in the area of cardiovascular regulation and disease

About cardiovascular regulation and disease research

The breadth of our experimental approaches includes cellular, animal and human models, and the complex interplay between risk factors such as diabetes, obesity or aging on cardiovascular physiological responses. Identifying therapeutic interventions such as the use of exercise or pharmaceutical targets are emphasized.


Is this option for me?

This option is for students who wish to study the causative factors of cardiovascular disease, as well as the effects of the disease on the human body.


Potential specialization areas

  • Hypertension/hypercholesterolemia
  • In vitro and in vivo animal models of ischemia/reperfusion injury
  • Mitochondrial dysfunction and signaling (respiration and proteomics)
  • Mechanisms of skin and leg blood flow in humans
  • Control of blood pressure in humans
  • Thermoregulatory mechanisms in humans
Lacy Alexander
Associate Professor of Kinesiology
Senior Research Associate

Dr. Alexander utilizes in vivo and in vitro approaches using the human cutaneous circulation to examine the underlying signaling mechanisms mediating microvascular dysfunction with primary human aging, hypercholesterolemia, and essential hypertension.
Peter J Butler

Fundamental molecular mechanisms by which vascular endothelial cells sense the forces from flowing blood and transduce this mechanical information into adjustments of cell and tissue biology.
Patrick James Drew
Assistant Professor of Engineering Science and Mechanics
Assistant Professor of Neurosurgery

Control and development of the cerebral blood flow, neurovascular coupling.
Pamela Hankey
Professor of Immunology

Donna Korzick
Professor of Physiology and Kinesiology
Chair, Intercollege Graduate Degree Program in Physiology

Effects of chronic endurance exercise and senescence on the regulation of cardiovascular function. Ischemia/reperfusion injury and the role of non-genomic estrogen receptor signaling in the aged female rat heart.
Herbert Lipowsky
Professor of Bioengineering

Keefe Manning
Associate Professor, Bioengineering and Surgery

Understanding the native cardiovascular system fluid mechanics; understanding the diseased cardiovascular system fluid mechanics, and the impact that cardiovascular prosthetics generate during and post implantation
James Pawelczyk
Associate Professor of Physiology and Kinesiology

Neural control of circulation, particularly skeletal muscle blood flow, as it is affected by exercise or spaceflight.
Greg Shearer
Assoc. Professor, Nutritional Sciences

We seek to understand disease-related functional changes in the context of global changes in lipid mediators (bioactive metabolites of dietary fatty acids) and use them to identify markers of disease and better ways to prevent or manage disease