Neurodegeneration in diabetic retinopathy. "This project studies the molecular and cellular mechanisms of neurodegeneration in diabetic retinopathy, a common complication of diabetes that can lead to vision loss. The lab examines how changes in visual function may be explained by degeneration in the synapses and neurons of the retina in diabetic animal models."
How interacting networks of transcription factors and signal transduction molecules guide the development of precursor/stem cells into mature neurons. Role of these networks in neurodegenerative diseases. Factors that can act as neuroprotective agents.
Mechanisms of calcium-induced signal transduction in brain, focusing on calmodulin-mediated enzymes. Isolation and characterization of novel, neuron-specific genes, with emphasis on those involved in neurotoxic actions of various agents.
Associate Professor, Neural and Behavioral Science
Dr. Holmes' research focuses upon derangements in autonomic nervous system
reflexes following traumatic brain or spinal cord injury. His laboratory
combines clinically relevant experimental models of brain and spinal cord injury
with physiological, neurochemical and immunohistochemical techniques. Particular
emphasis in his laboratory has been placed on gastrointestinal and reproductive
changes after injury.
We are interested in understanding how ion channels control signaling in
the nervous system. We focus on potassium channel-mediated control of
firing threshold and ionic mechanisms involved in the generation and
processing of sensory potentials. Our research relies on a combination
of mouse genetics, electrophysiology, cell biology and compound
Cellular and synaptic mechanisms that underlie the synchronous oscillatory activity in three different neural systems of the mammalian brain: the thalamo-cortical, limbic forebrain-habenular, and subthalamo-pallidal systems.
Neural Transplantation and gene therapy for neurodegenerative disorders. Basal ganglia pathophysiology. Stem cell biology and immunology of transplantation. Preclinical and clinical therapeutics in movement disorders.
Determine the mechanisms that maintain tolerance or induce T cell
responses to self antigens, resulting in resistance or susceptibility to
autoimmune diseases such as Multiple Sclerosis or Type 1 diabetes.