Regulation of gene expression underlying neonatal development & organ system physiology; mouse models of human congenital diseases including juvenile diabetes, metabolic disorders, skeletal dysplasias, and central nervous system dysfunctions.
Cancer genetics; Systems Genetics validation of candidate genes from
human genetics; skin color genetics; high-throughput automated
whole-body 3D genetic and chemical phenomics at cell resolutions in
interdisciplinary teams (physics, engineering, computer engineering,
heuristic computer vision, user interfaces); synchrotron microCT
imaging; genetics of genomic instability; web-based resources.
Chronic disease epidemiology; public health surveillance; Geographic Information System (GIS); cartography; community-based research; program evaluation; health disparities; Appalachian region; rural health; screening; prevention.
Growth factors and receptors in brain and heart development and cancer. The pentapeptide OGF and its receptor, OGFr; understanding the OGF-OGFr axis and its mechanisms of action in both normal and disease states.
Biophysical Chemistry applied to solution NMR spectroscopy of partially disordered proteins. NMR studies of protein dynamics coupled with computational and theoretical studies of the coupling between nuclear spin relaxation and molecular motion.
Mechanisms of action of hypolipidemic drugs and peroxisome proliferators; steroid hormone receptor-mediated signal transduction; signal transduction by lipids and fatty acids; receptor-mediated carcinogenesis.