People who work in Molecular and cellular immunology

Signal transduction pathways that regulate immune function; in particular, role of Tec family tyrosine kinases in T cells and mast cells. How manipulation of these signals affect immune response in diseases such as allergic asthma.

Cellular and molecular mechanisms underlying stress-induced, neuroendocrine-mediated modulation of the immune response to herpes simplex virus infections.

Vitamin D regulation of autoimmunity, especially inflammatory bowel diseases. Molecular and cellular regulation of host immunity, and regulation by nutrients.

Murine Stk receptor tyrosine kinase and its function in macrophage regulation and inflammation and in leukemic development.

Breast cancer and the immune system; how metastatic, osteolytic breast cancer cells affect osteoblasts.

The role of macrophages and dendritic cells in antigen presentation, antiviral immunity and in chronic inflammation during diabetes.

Fertility and reproductive immunology in domestic farm animals. Improving diagnosis of infertility and viral infections.

Roles of host genes in restricting infection by Friend erythroleukemia virus.

Surfactant regulation of lung immune cell function.

Regulation of immune function by oxidative stress and antioxidants, including selenium. Regulation of HIV transcription by selenium.

Vitamin A metabolism; hepatic retinoid function and gene expression; vitamin A in infection and immunity.

Hematopoietic stem cell transplantation.

Cellular immune responses in the control of cancer. Investigation of CD8+ T lymphocyte response in unique tumor environments to define immunotherapeutic approaches to cancer.

Molecular mechanisms responsible for recognition by macrophages of phosphatidylserine on apoptotic cell surfaces.

Neuro-endocrine modulation of dendritic cell function (maturation, antigen presentation, cytokine production, migration) in the initial steps of T cell-mediated anti-viral/tumor immunity.

Development and function of gamma/delta T cells, a class of immune cells with various roles in microbial immunity, inflammation regulation and tumor surveillance.