People who work in Host-pathogen interactions

Signal transduction pathways that regulate immune function; in particular, role of Tec family tyrosine kinases in T cells and mast cells. How manipulation of these signals affect immune response in diseases such as allergic asthma.

Cellular and molecular mechanisms underlying stress-induced, neuroendocrine-mediated modulation of the immune response to herpes simplex virus infections.

Molecular analysis of papillomavirus immunity.

Rhinitis and its effects on sleep and daytime somnolence; allergic rhinitis and asthma.

Mechanisms of environmental survival and virulence of pathogens associated with foodborne disease.

Investigating the pathogenic behavior of JC virus, especially in immunosuppressed individuals.

Understanding the structures and interactions between malaria parasites and human glycoconjugates that lead to malaria pathogenesis.

Interactions between bacterial pathogens and host immunology.

Viral pathogenesis focusing on the interactions between paramyxoviruses and hosts. Development of antiviral drugs and virus vectors, for vaccine development and gene therapy.

The pathogenesis of infectious disease: examining bacterial virulence and associated pathology in relation to host immune responses.

The role of macrophages and dendritic cells in antigen presentation, antiviral immunity and in chronic inflammation during diabetes.

Molecular mechanisms of virus and host adaptation at scales that span protein and structure to population dynamics.

Regulation of immune function by oxidative stress and antioxidants, including selenium. Regulation of HIV transcription by selenium.

Evolutionary ecology of host-parasite interactions, particularly virulence, infectiousness, vaccine-driven evolution, and drug and insecticide resistance.