Molecular Medicine offers rigorous training and research opportunities focused on mechanisms and treatment of disease. As a Molecular Medicine graduate student you will:
- Rotate in 3 research labs chosen from a world class faculty your first semester before choosing a research mentor.
- Take Core Courses that focus on basic biochemistry and molecular biology of the cell, pathobiology of human disease, and molecular concepts in the analysis of diseases.
- Choose from a substantial number of Elective Courses in conjunction with research mentor that allow you to develop your own curricula based on research focus.
- Be exposed to multiple research areas through invited speaker seminars and research presentations as well as on campus research symposia, conferences and workshops.
- Have access to Penn State's state-of-the-art microscopy, mouse, metabolomics, proteomics and bioinformatics facilities.
- Have the necessary training and research experience for jobs in research, teaching and regulatory positions in academia, government, private research institutions and pharmaceutical companies.
Faculty research interests include:
- Cancer Biology and Therapeutics: research focus on critical signaling pathways and molecules in cancer development, metastasis and treatment using cutting edge molecular and genomic methods and animalmodels of cancer.
- Autoimmune and Inflammatory Disease: research focus on allergic asthma and other autoimmune diseases such as diabetes, multiple sclerosis, and inflammatory bowel disease at the cellular and molecular level.
- Neurological and Neuropsychiatric Disorders: study of the molecular cellular and system wide function of the nervous system with emphasis on understanding mechanisms of disorders such as Alzheimer's, autism, epilepsy, depression and schizophrenia.
Bernhard Luscher Gong Chen Santhosh Girirajan Yingwei Mao
- Diabetes and Metabolic Disease
- Infectious Disease: research focus on the mechanisms of infection, transmission and therapy of viral, bacterial and parasitic pathogens, and the response of the host to infection.
Gary Perdew Robert Paulson Zhi-Chun Lai Joe Reese Yanming Wang
Recent publications from Molecular Medicine faculty:
- Girirajan et al., Refinement and discovery of new hotspots of copy-number variation associated with autism spectrum disorder. Am J Hum Genet 92:221-37, 2013. (Girirajan Lab)
- Peters et al., The role of peroxisome proliferator-activated receptors in carcinogenesis and chemoprevention Nature Rev Cancer 12:181-95, 2012. (Peters Lab)
- Lahoti et al., Aryl hydrocarbon receptor antagonism mitigates cytokine-mediated inflammatory signaling in primary human fibroblast-like synoviocytes. Ann Rheum Dis.72:1708-16, 2013. (Perdew Lab)
- Hu, S and Xiong, N. Programmed downregulation of CCR6 is important for establishment of epidermal γδT cells by regulating their thymic egress and epidermal location. J. Immunol. 190:3267-75, 2013. (Xiong Lab)
- Lodiero et al.,Transcription from the second heavy-strand promoter of human mtDNA is repressed by transcription factor A in vitro. Proc. Natl. Acad. Sci. USA 109:6513-8, 2012. (Cameron Lab)
- Gunderson et al.,CD8+ T cells mediate RAS-induced psoriasis-like skin inflammation through IFN-γ. J. Invest. Dermatol. 133:955-63, 2013. (Glick Lab)
- Khan, et al., MicroRNA-17~92 regulates effector and memory CD8 T-cell fates by modulating proliferation in response to infections. Blood 121:4473-83, 2013. (Kalia, Sarkar Labs)
- Shen et al., GABAergic control of critical developmental periods for anxiety and depression related behavior in mice. PLoS One 7:e7441, 2012. (Luscher Lab).