The Facility is specialized in four clusters – optical microscopy, electron microscopy, histology and flow cytometry – equipped with confocal microscopes, research fluorescence microscopes, transmission- and scanning electron microscopes, flow cytometers and a cell sorter, and whose research staff is engaged in experimentation, training, project collaboration and consultation.
Picture of the Month
The cover for the September 2016 issue of Disease Models and Mechanisms features work from the Penn State Biology Department (Ordway lab) on genetic analysis of tissue degeneration; a process which is strongly influenced by genetics, aging and environmental factors and leads to important degenerative diseases such as Alzheimer’s and Parkinson’s. In the image, a cross-section of the Drosophila thorax shows components of the flight motor, including the two stacks of six dorsal longitudinal muscle (DLM) fibers (top, center) and the ventral nerve cord of the central nervous system (CNS) (bottom, center). Motor axons project from the CNS to DLM muscle fibers where they form tripartite synapses comprised of a presynaptic neuron, a postsynaptic muscle and an associated perisynaptic glial cell. As reported in the enclosed article by Fumiko Kawasaki, Noelle Koonce, Linda Guo, Shahroz Fatima, Catherine Qiu, Mackenzie Moon, Yunzhen Zheng and Richard Ordway, the flight motor has been developed an experimental model for genetic analysis of environmental stress-induced degeneration.