François Major (Université de Montréal)
Simulating and Predicting the MicroTargetome
| When |
Tue Feb 14, 2012 04:00 pm — 05:00 pm |
|---|---|
| Where |
102 Chemistry Building
|
| Contact Person | Philip Bevilacqua |
| Add event to calendar |
vCal
iCal
|
More information about François Major…
Dr. Major is a faculty member at the Université de Montréal, in the Institute for Research in Immunology and Cancer, and the Department of Computer Science and Operations Research.
Abstract
Protein output determines cell types and states. In animals, microRNAs (miRNAs) are key actors in controlling protein output. Mature miRNAs are about 22-nucleotide long. They guide RNA-induced silencing complexes (RISCs) to bind to messenger RNAs (mRNAs) to repress their translation. Besides, recent studies indicate that various non-coding RNAs control protein output by competitive attraction of miRNAs. In this seminar, I will present an algorithm to predict the microTargetome (miRNA/mRNA matching) and results obtained from simulations in some NCI60 cell lines. This algorithm uses a simple hybridization model and considers all competing endogenous RNAs (ceRNAs). Since RNA levels vary in different cell types and states, including cancer cells, understanding and predicting microTargetome changes could thus bring us insights into the role of RNAs in cell differentiation, as well as in cancer development and progression.
Questions? Want to meet with the speaker?
Contact Philip Bevilacqua pcb5@psu.edu
