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Center for Reproductive Biology and Health

Center for Reproductive Biology and Health

Faculty who are deeply committed to the improvement of reproductive health and function through integration of fundamental and applied research and dissemination of knowledge
Center for Reproductive Biology and Health

Mouse oocyte from antral follicle. Note the very prominent nucleus, nucleolus and zona pellucida

The Center for Reproductive Biology and Health (CRBH) provides a forum for faculty to engage in discussion of new ideas, seek input on experimental designs, and broaden their perspectives on questions in reproductive biology.

The CRBH organizes workshops, seminars, and an annual retreat for presentation of recent data from member laboratories.

The breadth of expertise among CRBH faculty provides exceptional learning experiences for students in undergraduate and graduate classes, and ensures that outreach specialists convey the most accurate and up-to-date information.

Recent publications
Center for Reproductive Biology and Health Feed restriction inhibits early follicular development in broiler-breeder hens
Center for Reproductive Biology and Health Adipose tissue is a dynamic endocrine organ secreting a variety of hormones that affect physiological functions within the central nervous system, cardiovascular system, reproductive, and immune systems. The endocrine role of avian adipose tissue remains enigmatic as many of the classical hormones found in mammalian adipose tissue have not been found in avians. This mini-review summarizes our current knowledge on avian adiponectin, one of the most abundant adipose tissue hormones, and its receptors.
Center for Reproductive Biology and Health In the hen ovary, selection of a follicle into the preovulatory hierarchy occurs from a small cohort of prehierarchal (6-8 mm) follicles. Prior to follicle selection the granulosa layer remains in an undifferentiated state despite elevated follicle-stimulating hormone receptor (FSHR) expression. The present studies describe a role for bone morphogenetic protein 4 (BMP4) in supporting FSHR mRNA expression in granulosa cells from prehierarchal follicles and promoting differentiation at follicle selection
Female mice deprived of dietary zinc for a relatively short time before conception experienced fertility and pregnancy problems and had smaller, less-developed fetuses than mice that ingested zinc during the same times, according to Penn State researchers including Francisco Diaz and Thomas Neuberger. Zinc deficiency before conception disrupts fetal development - Full article
Huck Institutes affiliate Shannon Kelleher and Penn State graduate student Steve Hennigar advance scientists' understanding of zinc's role in breast development, lactation, and involution. Key factor in neonatal zinc deficiency may impact lactation and breast cancer - Full article
Kamat, a Ph.D. candidate in the Department of Animal Science, is a member of the graduate program in immunology and infectious disease. Kamat Places Third in 29th Annual University-wide Graduate Exhibition - Full article