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Center for Molecular Investigation of Neurological Disorders

Center for Molecular Investigation of Neurological Disorders

Facilitating research collaborations on neurological and neuropsychiatric disorders such as Alzheimer's, autism, epilepsy, depression, and schizophrenia

The Center for Molecular Investigation of Neurological Disorders (CMIND) facilitates research collaborations among its researchers and university wide.

Research laboratories include state of the art instrumentation for electrophysiology, imaging, molecular and cell biology, and behavioral analysis of mice.

Mission

The Center's mission is to use the latest and most appropriate tools to advance the understanding of molecular, cellular and system wide function of the nervous system, with special emphasis on mechanisms that regulate neural excitability, synaptic transmission and intracellular mechanisms of signal transduction that are relevant for understanding of neurological and neuropsychiatric disorders such as Alzheimer's, autism, epilepsy, depression, and schizophrenia.

Recent publications
Researchers identify gene required for nerve regeneration A team led by Melissa Rolls has found that a mutation in a single gene can completely shut down the process by which axons, nerve-cell components responsible for sending signals to other cells, regenerate after being damaged.
Protein required for flexible behavior is identified Researchers have identified in mice a protein that is necessary for maintaining behavioral flexibility, the ability to adapt to changing circumstances; their findings may offer new insights for addressing such human afflictions as autism and schizophrenia, in which this ability is significantly impaired.
New model synapse could shed light on disorders such as epilepsy and anxiety A team of scientists led by Huck Institutes faculty member Gong Chen has developed a new way to study the role of a critical neurotransmitter in disorders such as epilepsy, anxiety, insomnia, depression, schizophrenia, and alcohol addiction.
News
A new study by Huck Institutes faculty researcher Moriah Szpara and an international team of scientific collaborators begins the process of quantifying variation between the genomes of all known strains of herpes simplex virus (HSV) – a crucial step toward developing an effective vaccine. Quantifying the genomic variation of herpes viruses is a crucial step toward a vaccine - Full article
Tiny protein motors in cells can steer microtubules in the right direction through branching nerve cell structures, according to Huck Institutes faculty researchers Melissa Rolls and Will Hancock and graduate student Yalei Chen. Experiments show hypothesis of microtubule steering accurate - Full article
Penn State University molecular biologists – including Huck Institutes faculty member Melissa Rolls and graduate students Richard Albertson, Michelle Stone, and Li Chen – have discovered a brand-new pathway for repairing nerve cells that could have implications for faster and improved healing. A new pathway for neuron repair is discovered - Full article