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Center for Eukaryotic Gene Regulation

Center for Eukaryotic Gene Regulation

Fostering collaborative, interdisciplinary research into fundamental gene regulation processes and their impact on cellular and developmental biology

The Center for Eukaryotic Gene Regulation studies mechanisms of gene regulation through several different model organisms, including human tissue culture cells, fruit flies, and yeast.

We use these models to tease out the relationships between the numerous interacting factors responsible for gene regulation.

The Genome Cartography Project

The Center for Eukaryotic Gene Regulation also is part of the Genome Cartography Project — a collaboration with the Center for Comparative Genomics and Bioinformatics.

Recent publications
Researchers develop new method to pinpoint and study gene-regulating proteins B. Franklin Pugh and graduate student Ho Sung Rhee have published their results in Cell and Nature.
News
A duo of Penn State scientists that includes Huck Institutes affiliate B. Franklin Pugh has achieved a major milestone in understanding how genomic "dark matter" originates. Scientists discover the origins of genomic "dark matter" - Full article
The Huck Institutes wish to appoint a series of new Associate Directors to work with the management team and help in developing new initiatives. Huck Institutes seek new Associate Directors for positions in science leadership - Full article
By studying a gene in yeast, a team of scientists led by Huck Institutes affiliate Lu Bai has found that modifications to proteins associated with DNA can control whether or not a gene is allowed to function and may be important in maintaining a gene's "expression potential" so that future cells will behave as the parent cell did. Short-term gene-expression "memory" is inherited in proteins associated with DNA - Full article